Patient P-03380
Therapy response
Unstable
Tolerance
Favorable
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Favorable
Discontinuation risk
10%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S16
- Day 90 AD-05 recommended — Adherence Support AD-05
- Day 91 Patient accepted — Started AD-05 in the companion
- Day 96 GI symptom burden −14% vs expected — Adherence Support AD-05
- Day 102 Tolerance state changed — Unstable → Improving
- Day 111 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 111.
Primary contributors, last 14 days
- Inflammatory activity-7
- GI instability-6
- Toxicity-2
What helped?
- Adherence Support AD-05Day 90Result: symptom burden −14%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log6.3/10
stable · +0.1 vs previous 14 d
Stress level
Daily log4/10
stable · -0.1 vs previous 14 d
Pessimism score
Daily log5/10
worsening · +0.4 vs previous 14 d
Sleep quality
Wearable51.6/100
stable · +1.5 vs previous 14 d
Libido
Daily log5.2/10
improving · +0.2 vs previous 14 d
HRV
Wearable42.7 ms
worsening · -2.0 vs previous 14 d
Toxicity
Blood15.6/100
worsening · +2.0 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →Heading towards restoration · 76 from the failing basin, 45 from restoration.
Good elements to keep
- Adherence Support AD-05intervention · steering +21.5
- Protein (supports)perturbation · steering +9.7
- Butyrate producers intacthidden · steering +7.5
- Proteinsupporter · GI -5.3 next day
Main detractors to watch
- FUT2 non-secretorhidden · steering -10.6
- Histamine loadperturbation · steering -10.2
- Lactoseperturbation · steering -7.9
- Bacteroides fragilis elevatedhidden · steering -7.4
- Histamine loaddetractor · GI +4.8 next day
- Lactosedetractor · GI +4.4 next day
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.3supporter · 95%
- Histamine load+4.8detractor · 95%
- Lactose+4.4detractor · 95%
- Alcohol+2.6detractor · 71%
- Caffeine+2.3detractor · 59%
- Dietary fat load-0.7no signal · 17%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓45
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 69/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 47 ms
- Sleep
- 7.0 h
- Steps
- 7,333
- Resting HR
- 60 bpm
Daily log: GI score 10, nutritional resilience 70, adherence 85.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.