Patient P-03382
Therapy response
Stable
Tolerance
Stable
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Improving
Discontinuation risk
41%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S01
- Day 99 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient accepted — Started GI-04 in the companion
- Day 111 GI symptom burden −29% vs expected — GI Support Protocol GI-04
- Day 117 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 99.
Primary contributors, last 14 days
- Treatment adherence-10
- Nutritional resilience+4
- GI instability-2
What helped?
- GI Support Protocol GI-04Day 102Result: symptom burden −29%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
61%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log4.4/10
worsening · -0.2 vs previous 14 d
Stress level
Daily log6.4/10
stable · +0.2 vs previous 14 d
Pessimism score
Daily log5.8/10
worsening · +0.4 vs previous 14 d
Sleep quality
Wearable39.4/100
stable · +1.0 vs previous 14 d
Libido
Daily log2.8/10
stable · +0.0 vs previous 14 d
HRV
Wearable40.2 ms
improving · +2.0 vs previous 14 d
Toxicity
Blood45.4/100
worsening · +10.9 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 46 from the failing basin, 41 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 60%
- DT-01 Dosing / Timing Recommendation82% improved among 11 similar · onset 5 d · confidence 60%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 60%
- More proteinGI -6 next day on high-intake days · n 21
Would not help
- AD-05 Adherence Supportonly 30% improved among 10 similar
- Keep lactose lowGI +5 next day on high-intake days · n 17
- Keep histamine lowGI +4.4 next day on high-intake days · n 23
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-6supporter · 95%
- Lactose+5detractor · 95%
- Histamine load+4.4detractor · 95%
- Alcohol+1.7no signal · 38%
- Dietary fat load-0.1no signal · 15%
- Caffeine0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Autonomic recovery ↑65
- WearableResting HR 80 bpm
- Wearable3,486 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 45
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓25
- BloodInflammatory load index 46
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2.8 · butyrate capacity 48/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 5.9 h
- Steps
- 5,021
- Resting HR
- 79 bpm
Daily log: GI score 43, nutritional resilience 49, adherence 78.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.