Patient P-03390
Therapy response
Unstable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 59 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 73 ME-01 recommended — Monitoring Escalation ME-01
- Day 74 Patient accepted — Started ME-01 in the companion
- Day 77 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 59.
Primary contributors, last 14 days
- Toxicity+13
- GI instability-10
- Nutritional resilience+9
- Inflammatory activity-4
- Treatment adherence-3
What helped?
- Monitoring Escalation ME-01Day 73Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
90%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log1.9/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log6.9/10
stable · +0.2 vs previous 14 d
Pessimism score
Daily log6.1/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable6.5/100
improving · +2.6 vs previous 14 d
Libido
Daily log2.5/10
worsening · -0.2 vs previous 14 d
HRV
Wearable26.7 ms
stable · -0.4 vs previous 14 d
Toxicity
Blood53.1/100
worsening · +9.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 20 from the failing basin, 75 from restoration.
Would help
- GI-04 GI Support Protocol73% improved among 33 similar · onset 8 d · confidence 95%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 69%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 69%
- More proteinGI -4.4 next day on high-intake days · n 21
- More caffeineGI -2.1 next day on high-intake days · n 15
Would not help
- AD-05 Adherence Supportonly 23% improved among 13 similar
- Keep fat lowGI +3.7 next day on high-intake days · n 19
- Keep histamine lowGI +3.3 next day on high-intake days · n 22
- Keep lactose lowGI +3 next day on high-intake days · n 17
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.4supporter · 95%
- Dietary fat load+3.7detractor · 95%
- Histamine load+3.3detractor · 95%
- Lactose+3detractor · 91%
- Caffeine-2.1supporter · 69%
- Alcohol-1.2no signal · 31%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 30/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑65
- WearableResting HR 79 bpm
- Wearable1,792 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 70 and rising
- WearableSleep 4.6 h, below personal baseline
- Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- WearableHRV 27 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 53
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.6 · butyrate capacity 30/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 26 ms
- Sleep
- 5.0 h
- Steps
- 2,312
- Resting HR
- 79 bpm
Daily log: GI score 70, nutritional resilience 42, adherence 42.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.