Patient P-03451
Therapy response
Favorable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
54%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S08
- Day 100 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 100.
Primary contributors, last 14 days
- Treatment adherence-15
- Toxicity+8
- Nutritional resilience+4
- GI instability+2
- Inflammatory activity+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.8/10
worsening · -1.3 vs previous 14 d
Stress level
Daily log5.7/10
worsening · +0.7 vs previous 14 d
Pessimism score
Daily log5.3/10
worsening · +0.2 vs previous 14 d
Sleep quality
Wearable27.4/100
worsening · -11.2 vs previous 14 d
Libido
Daily log2.8/10
worsening · -0.8 vs previous 14 d
HRV
Wearable50.5 ms
worsening · -6.7 vs previous 14 d
Toxicity
Blood43.8/100
worsening · +12.1 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 41 from the failing basin, 56 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 34 similar · onset 8 d · confidence 60%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 62%
- DT-01 Dosing / Timing Recommendation82% improved among 11 similar · onset 5 d · confidence 62%
- More proteinGI -5.4 next day on high-intake days · n 21
Would not help
- AD-05 Adherence Supportonly 22% improved among 9 similar
- Keep fat lowGI +4.4 next day on high-intake days · n 21
- Keep histamine lowGI +4 next day on high-intake days · n 16
- Keep lactose lowGI +3.1 next day on high-intake days · n 16
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.4supporter · 95%
- Dietary fat load+4.4detractor · 95%
- Histamine load+4detractor · 95%
- Lactose+3.1detractor · 86%
- Caffeine+1.1no signal · 22%
- Alcohol+0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 27/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 59 and rising
- WearableSleep 6.1 h, below personal baseline
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 57
- Autonomic recovery ↓45
- WearableResting HR 73 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 44
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 3.2 · butyrate capacity 27/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 52 ms
- Sleep
- 6.2 h
- Steps
- 6,066
- Resting HR
- 73 bpm
Daily log: GI score 59, nutritional resilience 43, adherence 70.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.