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Patient P-02051

Synthetic patientMETA-24 · Day 172 · 75+ · F · baseline S14Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Stable
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Stable
Discontinuation risk
59%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 META-24 started — Baseline state S14
  2. Day 47 NP-02 recommended — Dietary Support Protocol NP-02
  3. Day 48 Patient accepted — Started NP-02 in the companion
  4. Day 58 GI symptom burden −26% vs expected — Dietary Support Protocol NP-02
  5. Day 64 Tolerance state changed — Unstable → Improving
  6. Day 74 GI-04 recommended — GI Support Protocol GI-04
  7. Day 74 SC-12 recommended — Supportive Compound SC-12
  8. Day 75 Patient accepted — Started GI-04 in the companion
  9. Day 75 Patient declined — Not now
  10. Day 83 GI symptom burden −31% vs expected — GI Support Protocol GI-04
  11. Day 85 Trajectory diverged from prediction — Observed response fell below the model's expected path.
  12. Day 88 ME-01 recommended — Monitoring Escalation ME-01
  13. Day 89 Tolerance state changed — Unstable → Improving
  14. Day 89 Patient accepted — Started ME-01 in the companion
  15. Day 92 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 85.

Primary contributors, last 14 days
  • GI instability-10
  • Inflammatory activity-7
  • Treatment adherence+5

What helped?

  • Dietary Support Protocol NP-02Day 47
    Result: symptom burden −26%
  • GI Support Protocol GI-04Day 74
    Result: symptom burden −31%
  • Supportive Compound SC-12Day 74
    Declined by patient
  • Monitoring Escalation ME-01Day 88
    Result: deterioration detected before clinical escalation
LIFE OS recommendation
Supportive Compound SC-12
54%
probability of meaningful tolerance improvement
  • 284 similar trajectories
  • 69% showed improvement
  • median effect visible after 6 days
View similar patientsSimulateAdd to intervention cohortAll evidence

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes
Wearable
49 min
stable · -1.0 vs previous 14 d
Sleep duration
Wearable
6.5 h
stable · +0.1 vs previous 14 d
Energy level
Daily log
3.8/10
stable · +0.1 vs previous 14 d
Steps
Wearable
6,045
stable · -131 vs previous 14 d
GI burden
Companion
40.3/100
worsening · +2.3 vs previous 14 d
Adherence
Companion
53.3 %
worsening · -2.7 vs previous 14 d
Sleep quality
Wearable
52/100
stable · +0.0 vs previous 14 d
Glucose, CGM daily mean
CGM
146 mg/dL
stable · +0.1 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →

Heading towards restoration · 41 from the failing basin, 47 from restoration.

Good elements to keep
  • GI Support Protocol GI-04
    intervention · steering +42.2
  • Dietary Support Protocol NP-02
    intervention · steering +25.3
  • Protein (supports)
    perturbation · steering +9.5
  • Butyrate producers intact
    hidden · steering +7.5
  • Protein
    supporter · GI -5 next day
Main detractors to watch
  • Poor metabolizer
    hidden · steering -12.7
  • FUT2 non-secretor
    hidden · steering -10.6
  • Caffeine
    perturbation · steering -9.6
  • IL6 high-expression variant
    hidden · steering -7.3
  • Caffeine
    detractor · GI +5.5 next day
  • Ultra-processed food
    detractor · GI +4.8 next day
State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

  • Caffeine
    +5.5detractor · 95%
  • Protein
    -5supporter · 95%
  • Ultra-processed food
    +4.8detractor · 95%
  • Histamine load
    +4.4detractor · 95%
  • Alcohol
    +3.7detractor · 83%
  • Insoluble fibre
    -1no signal · 21%
  • Dietary fat load
    +0.8no signal · 15%
  • Simple carbohydrates
    +0.7no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure
  • Mucosal barrier integrity ↓60
    • DNAFUT2 non-secretor lowers mucosal fucosylation
    • MicrobiomeAkkermansia low → thinner mucus layer
  • Drug metabolism and exposure ↑60
    • DNACYP2D6 poor metabolizer → higher exposure
    • BloodToxicity index 48
  • Inflammatory signalling ↓50
    • DNAIL6 -174 variant raises baseline inflammatory tone
    • BloodInflammatory load index 46
  • Butyrate / short-chain fatty acid production ↓45
    • MicrobiomeF. prausnitzii depleted
    • Daily logFibre intake low in recent food logs
DNA
Fictional pharmacogenomic panel
  • FUT2 rs601338 AA (non-secretor)
    Reduced mucosal fucosylation
  • IL6 -174 G/C
    Higher inflammatory tone
  • CYP2D6 Poor metabolizer
    Higher exposure at standard dose
Microbiome
Shannon diversity 3.2 · butyrate capacity 47/100
  • Akkermansia muciniphilaLow
  • Faecalibacterium prausnitziiLow
  • Bacteroides fragilisNormal
  • Bifidobacterium longumLow
  • EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
HRV
57 ms
Sleep
6.4 h
Steps
5,618
Resting HR
64 bpm
Daily log: GI score 40, nutritional resilience 46, adherence 53.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview
What to eat
  • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
  • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
  • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
  • Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
  • Track each bowel movement today: time, stool form, urgency, overnight waking
  • Keep the current walking rhythm
  • Keep the sleep window steady
  • Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
  • Take the dose at the same time relative to your evening meal
  • Electrolyte solution, one sachet after any loose stool
  • Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
PatientSimilarityBaselineInterventionOutcomeResponse today
P-0241042%S01GI-04improved55
P-0201838%S01GI-04improved46
P-0205433%S01CR-01improved57
P-0240926%S01SC-12no change54
P-0230725%S01——55
P-0243725%S01——64
P-0259825%S01——53
P-0204124%S01——27
P-0208724%S01BR-03no change40
P-0221724%S01——61
P-0227624%S01——57
P-0252224%S01BR-03no change40