Patient P-02084

Synthetic patientMETA-24 · Day 168 · 25–34 · F · baseline S11Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Deteriorating

Inflammatory state

Stable

Nutritional resilience

Stable

Discontinuation risk

57%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S11
Day 122 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 122 GI-04 recommended — GI Support Protocol GI-04
Day 123 Patient accepted — Started GI-04 in the companion
Day 131 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 122.

Primary contributors, last 14 days

GI instability+4
Treatment adherence+3
Toxicity+3
Inflammatory activity+2

What helped?

GI Support Protocol GI-04Day 122
Result: no meaningful change

LIFE OS recommendation

Monitoring Escalation ME-01

77%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

36 min

worsening · -3.8 vs previous 14 d

Sleep duration

Wearable

5.5 h

stable · -0.1 vs previous 14 d

Energy level

Daily log

2.2/10

improving · +0.1 vs previous 14 d

Steps

Wearable

3,511

worsening · -551 vs previous 14 d

GI burden

Companion

55.4/100

stable · -1.8 vs previous 14 d

Adherence

Companion

68.3 %

worsening · -7.9 vs previous 14 d

Sleep quality

Wearable

19.4/100

worsening · -3.0 vs previous 14 d

Glucose, CGM daily mean

CGM

148 mg/dL

stable · +1.8 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 40 from the failing basin, 52 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 42 similar · onset 3 d · confidence 65%
NP-02 Dietary Support Protocol
59% improved among 32 similar · onset 10 d · confidence 65%
SC-12 Supportive Compound
67% improved among 27 similar · onset 6 d · confidence 65%
More protein
GI -4.6 next day on high-intake days · n 25

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep fat low
GI +3.9 next day on high-intake days · n 23
Keep alcohol low
GI +3.9 next day on high-intake days · n 20
Keep ultra-processed low
GI +3.6 next day on high-intake days · n 24

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-4.6supporter · 95%
Dietary fat load
+3.9detractor · 95%
Alcohol
+3.9detractor · 95%
Ultra-processed food
+3.6detractor · 95%
Simple carbohydrates
+0.5no signal · 15%
Histamine load
-0.3no signal · 15%
Insoluble fibre
+0.3no signal · 15%
Caffeine
+0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 53
- WearableHRV 24 ms, trending down
Autonomic recovery ↓65
- WearableResting HR 78 bpm
- Wearable3,511 steps/day
- WearableShort sleep window
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 32/100
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓30
- Daily logGI symptom score 55 and rising
- WearableSleep 5.5 h, below personal baseline
Drug metabolism and exposure ↑20
- BloodToxicity index 48

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Rapid metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3.2 · butyrate capacity 32/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 27 ms
Sleep: 5.5 h
Steps: 3,550
Resting HR: 78 bpm

Daily log: GI score 55, nutritional resilience 43, adherence 68.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02483	24%	S06	BR-03	no change	64
P-02151	49%	S04	CR-01	improved	49
P-02054	48%	S01	CR-01	improved	57
P-02025	43%	S15	CR-01	improved	61
P-02009	37%	S08	CR-01	improved	64
P-02233	37%	S16	CR-01	improved	66
P-02154	34%	S16	CR-01	improved	57
P-02491	24%	S09	DT-01	no change	65
P-02395	23%	S12	DT-01	improved	57
P-02274	22%	S15	DT-01	improved	50
P-02339	22%	S03	DT-01	improved	50
P-02518	22%	S17	DT-01	improved	68