Patient P-02160
Therapy response
Declining
Tolerance
Stable
GI state
Improving
Inflammatory state
Stable
Nutritional resilience
Improving
Discontinuation risk
43%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S03
- Day 70 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 70.
Primary contributors, last 14 days
- Treatment adherence-12
- GI instability-6
- Nutritional resilience+4
- Toxicity-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
55%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 85% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 23/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 50
- WearableHRV 23 ms, trending down
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Autonomic recovery ↑45
- WearableResting HR 77 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 45
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 1.9 · butyrate capacity 23/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 22 ms
- Sleep
- 5.7 h
- Steps
- 6,662
- Resting HR
- 78 bpm
Daily log: GI score 44, nutritional resilience 49, adherence 74.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02078 | 43% | S04 | — | — | 56 |
| P-02433 | 42% | S07 | GI-04 | improved | 61 |
| P-02240 | 40% | S20 | GI-04 | improved | 57 |
| P-02321 | 39% | S17 | GI-04 | improved | 54 |
| P-02595 | 37% | S02 | — | — | 53 |
| P-02054 | 36% | S01 | CR-01 | improved | 57 |
| P-02084 | 36% | S11 | GI-04 | no change | 58 |
| P-02108 | 36% | S14 | GI-04 | improved | 43 |
| P-02334 | 36% | S04 | GI-04 | improved | 66 |
| P-02229 | 35% | S20 | — | — | 56 |
| P-02233 | 35% | S16 | CR-01 | improved | 66 |
| P-02236 | 35% | S14 | GI-04 | improved | 45 |