Patient P-02252
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
69%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S02
- Day 29 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 29.
Primary contributors, last 14 days
- GI instability+18
- Inflammatory activity+18
- Toxicity+16
- Treatment adherence-12
- Nutritional resilience-11
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
58%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 87% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 57 and rising
- WearableSleep 5.9 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 40/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 57
- Autonomic recovery ↓40
- Wearable505 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 43
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 40/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 46 ms
- Sleep
- 6.6 h
- Steps
- 1,663
- Resting HR
- 65 bpm
Daily log: GI score 57, nutritional resilience 42, adherence 80.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02483 | 32% | S06 | BR-03 | no change | 64 |
| P-02087 | 25% | S01 | BR-03 | no change | 40 |
| P-02280 | 25% | S07 | BR-03 | no change | 50 |
| P-02233 | 38% | S16 | CR-01 | improved | 66 |
| P-02009 | 36% | S08 | CR-01 | improved | 64 |
| P-02054 | 31% | S01 | CR-01 | improved | 57 |
| P-02154 | 29% | S16 | CR-01 | improved | 57 |
| P-02354 | 26% | S01 | CR-01 | improved | 78 |
| P-02025 | 25% | S15 | CR-01 | improved | 61 |
| P-02151 | 25% | S04 | CR-01 | improved | 49 |
| P-02395 | 30% | S12 | DT-01 | improved | 57 |
| P-02491 | 30% | S09 | DT-01 | no change | 65 |