Patient P-02309
Synthetic patientMETA-24 · Day 128 · 45–54 · M · baseline S09Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
55%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S09
- Day 18 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 18.
Primary contributors, last 14 days
- Toxicity+12
- GI instability+11
- Treatment adherence-11
- Inflammatory activity+8
- Nutritional resilience-8
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
61%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable75 min
worsening · -3.4 vs previous 14 d
Sleep duration
Wearable6.2 h
stable · -0.0 vs previous 14 d
Energy level
Daily log3.3/10
worsening · -0.7 vs previous 14 d
Steps
Wearable8,078
worsening · -532 vs previous 14 d
GI burden
Companion53.3/100
worsening · +8.0 vs previous 14 d
Adherence
Companion85.8 %
stable · -2.4 vs previous 14 d
Sleep quality
Wearable31.5/100
worsening · -3.4 vs previous 14 d
Glucose, CGM daily mean
CGM151 mg/dL
stable · +3.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 50 from the failing basin, 45 from restoration.
Would help
- GI-04 GI Support Protocol82% improved among 44 similar · onset 8 d · confidence 59%
- ME-01 Monitoring Escalation100% improved among 19 similar · onset 3 d · confidence 65%
- DT-01 Dosing / Timing Recommendation73% improved among 11 similar · onset 5 d · confidence 65%
- More proteinGI -3.3 next day on high-intake days · n 19
Would not help
- Keep alcohol lowGI +3.4 next day on high-intake days · n 22
- Keep histamine lowGI +3.3 next day on high-intake days · n 19
- Keep ultra-processed lowGI +2.9 next day on high-intake days · n 22
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Alcohol+3.4detractor · 95%
- Histamine load+3.3detractor · 95%
- Protein-3.3supporter · 95%
- Ultra-processed food+2.9detractor · 95%
- Simple carbohydrates+0.8no signal · 19%
- Caffeine-0.4no signal · 15%
- Insoluble fibre+0.3no signal · 15%
- Dietary fat load-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 47
- Autonomic recovery ↑45
- WearableResting HR 84 bpm
- WearableShort sleep window
- Butyrate / short-chain fatty acid production ↓20
- Daily logFibre intake low in recent food logs
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
Microbiome
Shannon diversity 3 · butyrate capacity 45/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 42 ms
- Sleep
- 7.2 h
- Steps
- 8,134
- Resting HR
- 82 bpm
Daily log: GI score 53, nutritional resilience 45, adherence 86.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02598 | 35% | S01 | — | — | 53 |
| P-02054 | 33% | S01 | CR-01 | improved | 57 |
| P-02307 | 33% | S01 | — | — | 55 |
| P-02437 | 32% | S01 | — | — | 64 |
| P-02276 | 31% | S01 | — | — | 57 |
| P-02550 | 31% | S01 | — | — | 70 |
| P-02354 | 29% | S01 | CR-01 | improved | 78 |
| P-02424 | 28% | S01 | — | — | 62 |
| P-02568 | 28% | S01 | — | — | 51 |
| P-02620 | 28% | S01 | HY-01 | improved | 64 |
| P-02018 | 27% | S01 | GI-04 | improved | 46 |
| P-02087 | 27% | S01 | BR-03 | no change | 40 |