Patient P-02310
Therapy response
Unstable
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
70%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 47 NP-02 recommended — Dietary Support Protocol NP-02
- Day 48 Patient accepted — Started NP-02 in the companion
- Day 58 GI symptom burden −18% vs expected — Dietary Support Protocol NP-02
- Day 64 Tolerance state changed — Unstable → Improving
- Day 69 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 78 GI-04 recommended — GI Support Protocol GI-04
- Day 79 Patient accepted — Started GI-04 in the companion
- Day 87 GI symptom burden −31% vs expected — GI Support Protocol GI-04
- Day 93 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 69.
Primary contributors, last 14 days
- Inflammatory activity+7
- Treatment adherence-5
- Toxicity+5
- GI instability+3
What helped?
- Dietary Support Protocol NP-02Day 47Result: symptom burden −18%
- GI Support Protocol GI-04Day 78Result: symptom burden −31%
LIFE OS recommendation
Monitoring Escalation ME-01
80%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable5 min
worsening · -5.2 vs previous 14 d
Sleep duration
Wearable7.1 h
worsening · -0.3 vs previous 14 d
Energy level
Daily log3.1/10
worsening · -0.7 vs previous 14 d
Steps
Wearable1,003
worsening · -592 vs previous 14 d
GI burden
Companion51.4/100
worsening · +7.8 vs previous 14 d
Adherence
Companion51.6 %
worsening · -3.3 vs previous 14 d
Sleep quality
Wearable53.5/100
worsening · -4.8 vs previous 14 d
Glucose, CGM daily mean
CGM148 mg/dL
stable · +4.1 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 24 from the failing basin, 63 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 41 similar · onset 3 d · confidence 68%
- SC-12 Supportive Compound69% improved among 26 similar · onset 6 d · confidence 68%
- CR-01 Clinician Review100% improved among 6 similar · onset 5 d · confidence 68%
- More proteinGI -5.1 next day on high-intake days · n 20
Would not help
- Keep fat lowGI +4.6 next day on high-intake days · n 21
- Keep histamine lowGI +4 next day on high-intake days · n 22
- Keep ultra-processed lowGI +2.3 next day on high-intake days · n 14
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.1supporter · 95%
- Dietary fat load+4.6detractor · 95%
- Histamine load+4detractor · 95%
- Ultra-processed food+2.3detractor · 83%
- Simple carbohydrates+2detractor · 61%
- Insoluble fibre-0.6no signal · 15%
- Alcohol-0.2no signal · 15%
- Caffeine+0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 51 and rising
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 29/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 55
- Autonomic recovery ↑45
- WearableResting HR 75 bpm
- Wearable1,003 steps/day
- Drug metabolism and exposure ↑20
- BloodToxicity index 48
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.4 · butyrate capacity 29/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 53 ms
- Sleep
- 7.2 h
- Steps
- 956
- Resting HR
- 76 bpm
Daily log: GI score 51, nutritional resilience 41, adherence 52.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02018 | 42% | S01 | GI-04 | improved | 46 |
| P-02410 | 42% | S01 | GI-04 | improved | 55 |
| P-02054 | 32% | S01 | CR-01 | improved | 57 |
| P-02409 | 28% | S01 | SC-12 | no change | 54 |
| P-02041 | 22% | S01 | — | — | 27 |
| P-02307 | 22% | S01 | — | — | 55 |
| P-02598 | 22% | S01 | — | — | 53 |
| P-02087 | 21% | S01 | BR-03 | no change | 40 |
| P-02217 | 21% | S01 | — | — | 61 |
| P-02276 | 21% | S01 | — | — | 57 |
| P-02375 | 21% | S01 | — | — | 44 |
| P-02437 | 21% | S01 | — | — | 64 |