Patient P-02318

Synthetic patientMETA-24 · Day 99 · 55–64 · M · baseline S14Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Improving

Nutritional resilience

Unstable

Discontinuation risk

65%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 71 GI-04 recommended — GI Support Protocol GI-04
Day 72 Patient accepted — Started GI-04 in the companion
Day 75 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 80 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 75.

Primary contributors, last 14 days

Treatment adherence-17
Toxicity+5
Inflammatory activity-4
Nutritional resilience-2

What helped?

GI Support Protocol GI-04Day 71
Result: no meaningful change

LIFE OS recommendation

Monitoring Escalation ME-01

86%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 25/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 56
- WearableHRV 17 ms, trending down
Autonomic recovery ↓45
- WearableResting HR 80 bpm
- WearableShort sleep window
Mucosal barrier integrity ↓20
- Daily logGI symptom score 64 and rising
Drug metabolism and exposure ↑20
- BloodToxicity index 45

DNA

Fictional pharmacogenomic panel

CYP2D6 Rapid metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 2.3 · butyrate capacity 25/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 19 ms
Sleep: 5.8 h
Steps: 5,505
Resting HR: 79 bpm

Daily log: GI score 64, nutritional resilience 38, adherence 72.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02666	44%	S14	ME-01	improved	51
P-02508	39%	S14	ME-01	improved	51
P-02165	38%	S14	ME-01	improved	59
P-02409	38%	S01	SC-12	no change	54
P-02060	36%	S14	GI-04	improved	54
P-02575	36%	S14	ME-01	improved	73
P-02102	34%	S14	GI-04	improved	64
P-02381	34%	S14	SC-12	improved	52
P-02433	34%	S07	GI-04	improved	61
P-02334	33%	S04	GI-04	improved	66
P-02046	32%	S10	—	—	55
P-02084	32%	S11	GI-04	no change	58