Patient P-02318
Therapy response
Declining
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Improving
Nutritional resilience
Unstable
Discontinuation risk
65%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 71 GI-04 recommended — GI Support Protocol GI-04
- Day 72 Patient accepted — Started GI-04 in the companion
- Day 75 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 80 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 75.
Primary contributors, last 14 days
- Treatment adherence-17
- Toxicity+5
- Inflammatory activity-4
- Nutritional resilience-2
What helped?
- GI Support Protocol GI-04Day 71Result: no meaningful change
LIFE OS recommendation
Monitoring Escalation ME-01
86%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 25/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 56
- WearableHRV 17 ms, trending down
- Autonomic recovery ↓45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓20
- Daily logGI symptom score 64 and rising
- Drug metabolism and exposure ↑20
- BloodToxicity index 45
DNA
Fictional pharmacogenomic panel
- CYP2D6 Rapid metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
Microbiome
Shannon diversity 2.3 · butyrate capacity 25/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 19 ms
- Sleep
- 5.8 h
- Steps
- 5,505
- Resting HR
- 79 bpm
Daily log: GI score 64, nutritional resilience 38, adherence 72.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.