Patient P-02348

Synthetic patientMETA-24 · Day 177 · 55–64 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

85%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 47 NP-02 recommended — Dietary Support Protocol NP-02
Day 48 Patient accepted — Started NP-02 in the companion
Day 58 No meaningful change — Dietary Support Protocol NP-02
Day 71 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 71 GI-04 recommended — GI Support Protocol GI-04
Day 72 Patient accepted — Started GI-04 in the companion
Day 80 GI symptom burden −22% vs expected — GI Support Protocol GI-04
Day 86 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 71.

Primary contributors, last 14 days

Inflammatory activity+7
GI instability+6
Toxicity+2

What helped?

Dietary Support Protocol NP-02Day 47
Result: no meaningful change
GI Support Protocol GI-04Day 71
Result: symptom burden −22%

LIFE OS recommendation

Monitoring Escalation ME-01

82%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

4 min

improving · +6.6 vs previous 14 d

Sleep duration

Wearable

5.6 h

stable · -0.1 vs previous 14 d

Energy level

Daily log

2.8/10

worsening · -0.4 vs previous 14 d

Steps

Wearable

635

improving · +454 vs previous 14 d

GI burden

Companion

67.8/100

worsening · +5.6 vs previous 14 d

Adherence

Companion

44.1 %

stable · -0.1 vs previous 14 d

Sleep quality

Wearable

17/100

worsening · -4.6 vs previous 14 d

Glucose, CGM daily mean

CGM

152 mg/dL

stable · +2.7 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 26 from the failing basin, 70 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 42 similar · onset 3 d · confidence 70%
SC-12 Supportive Compound
69% improved among 26 similar · onset 6 d · confidence 70%
CR-01 Clinician Review
100% improved among 6 similar · onset 5 d · confidence 70%
More protein
GI -5.1 next day on high-intake days · n 22

Would not help

NP-02 Dietary Support Protocol
already tried, no meaningful change
Keep alcohol low
GI +5.2 next day on high-intake days · n 24
Keep ultra-processed low
GI +5 next day on high-intake days · n 21
Keep simple carbs low
GI +4.5 next day on high-intake days · n 25

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Alcohol
+5.2detractor · 95%
Protein
-5.1supporter · 95%
Ultra-processed food
+5detractor · 95%
Simple carbohydrates
+4.5detractor · 95%
Dietary fat load
+3.1detractor · 86%
Insoluble fibre
+2.6detractor · 61%
Histamine load
-1.1no signal · 24%
Caffeine
+0.9no signal · 19%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 62
- WearableHRV 34 ms, trending down
Autonomic recovery ↓65
- WearableResting HR 80 bpm
- Wearable635 steps/day
- WearableShort sleep window
Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 68 and rising
- WearableSleep 5.6 h, below personal baseline
Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Drug metabolism and exposure ↑20
- BloodToxicity index 51

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.4 · butyrate capacity 47/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 34 ms
Sleep: 5.7 h
Steps: 1,385
Resting HR: 81 bpm

Daily log: GI score 68, nutritional resilience 34, adherence 44.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02018	52%	S01	GI-04	improved	46
P-02410	40%	S01	GI-04	improved	55
P-02409	35%	S01	SC-12	no change	54
P-02054	32%	S01	CR-01	improved	57
P-02307	21%	S01	—	—	55
P-02598	20%	S01	—	—	53
P-02041	19%	S01	—	—	27
P-02276	19%	S01	—	—	57
P-02437	19%	S01	—	—	64
P-02550	19%	S01	—	—	70
P-02568	19%	S01	—	—	51
P-02087	18%	S01	BR-03	no change	40