Patient P-02414

Synthetic patientMETA-24 · Day 173 · 35–44 · F · baseline S13Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Deteriorating

Inflammatory state

Favorable

Nutritional resilience

Favorable

Discontinuation risk

38%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S13
Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 22 HY-01 recommended — Hydration Protocol HY-01
Day 23 Patient accepted — Started HY-01 in the companion
Day 27 GI symptom burden −23% vs expected — Hydration Protocol HY-01
Day 33 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 15.

Primary contributors, last 14 days

GI instability+17
Toxicity-14
Inflammatory activity+4
Nutritional resilience-2
Treatment adherence+2

What helped?

Hydration Protocol HY-01Day 22
Result: symptom burden −23%

LIFE OS recommendation

Dosing / Timing Recommendation DT-01

53%

probability of meaningful tolerance improvement

284 similar trajectories
75% showed improvement
median effect visible after 5 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

73 min

worsening · -3.0 vs previous 14 d

Sleep duration

Wearable

5 h

stable · -0.1 vs previous 14 d

Energy level

Daily log

5.2/10

stable · -0.0 vs previous 14 d

Steps

Wearable

8,207

worsening · -339 vs previous 14 d

GI burden

Companion

39.2/100

worsening · +2.1 vs previous 14 d

Adherence

Companion

96.8 %

stable · -2.1 vs previous 14 d

Sleep quality

Wearable

19.3/100

worsening · -4.2 vs previous 14 d

Glucose, CGM daily mean

CGM

143 mg/dL

stable · +2.1 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 60 from the failing basin, 30 from restoration.

Would help

DT-01 Dosing / Timing Recommendation
75% improved among 16 similar · onset 5 d · confidence 55%
More protein
GI -5.5 next day on high-intake days · n 20

Would not help

Keep histamine low
GI +7.1 next day on high-intake days · n 16
Keep alcohol low
GI +6.8 next day on high-intake days · n 20
Keep ultra-processed low
GI +5.8 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+7.1detractor · 95%
Alcohol
+6.8detractor · 95%
Ultra-processed food
+5.8detractor · 95%
Protein
-5.5supporter · 95%
Simple carbohydrates
+5.4detractor · 95%
Dietary fat load
+5detractor · 95%
Insoluble fibre
-1.5no signal · 23%
Caffeine
+0.9no signal · 16%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑60
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 32 ms, trending down
Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 5.0 h, below personal baseline
Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 41/100
Autonomic recovery ↑20
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 2.1 · butyrate capacity 41/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 35 ms
Sleep: 6.1 h
Steps: 7,198
Resting HR: 69 bpm

Daily log: GI score 39, nutritional resilience 61, adherence 97.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02218	38%	S01	DT-01	improved	61
P-02276	37%	S01	—	—	57
P-02598	36%	S01	—	—	53
P-02307	35%	S01	—	—	55
P-02354	34%	S01	CR-01	improved	78
P-02568	34%	S01	—	—	51
P-02620	34%	S01	HY-01	improved	64
P-02681	33%	S01	—	—	51
P-02087	32%	S01	BR-03	no change	40
P-02437	31%	S01	—	—	64
P-02550	31%	S01	—	—	70
P-02424	30%	S01	—	—	62