Patient P-02444
Synthetic patientMETA-24 · Day 168 · 55–64 · F · baseline S07Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
68%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S07
- Day 128 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 128.
Primary contributors, last 14 days
- Treatment adherence-12
- Toxicity+9
- Inflammatory activity+8
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
72%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable11 min
worsening · -3.0 vs previous 14 d
Sleep duration
Wearable4.4 h
worsening · -0.3 vs previous 14 d
Energy level
Daily log2/10
worsening · -0.3 vs previous 14 d
Steps
Wearable300
worsening · -441 vs previous 14 d
GI burden
Companion75.2/100
worsening · +6.9 vs previous 14 d
Adherence
Companion61.3 %
worsening · -11.6 vs previous 14 d
Sleep quality
Wearable0/100
worsening · -6.5 vs previous 14 d
Glucose, CGM daily mean
CGM164 mg/dL
stable · +6.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 36 from the failing basin, 78 from restoration.
Would help
- GI-04 GI Support Protocol75% improved among 65 similar · onset 8 d · confidence 68%
- ME-01 Monitoring Escalation100% improved among 42 similar · onset 3 d · confidence 72%
- NP-02 Dietary Support Protocol59% improved among 32 similar · onset 10 d · confidence 72%
- More proteinGI -5.1 next day on high-intake days · n 22
Would not help
- Keep histamine lowGI +5.9 next day on high-intake days · n 19
- Keep fat lowGI +5.5 next day on high-intake days · n 17
- Keep ultra-processed lowGI +4.5 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.9detractor · 95%
- Dietary fat load+5.5detractor · 95%
- Protein-5.1supporter · 95%
- Ultra-processed food+4.5detractor · 95%
- Alcohol+3.3detractor · 77%
- Caffeine+1.6no signal · 33%
- Simple carbohydrates-0.3no signal · 15%
- Insoluble fibre-0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 75 and rising
- WearableSleep 4.4 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 72
- WearableHRV 32 ms, trending down
- Autonomic recovery ↑40
- Wearable300 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 54
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 34 ms
- Sleep
- 4.8 h
- Steps
- 1,320
- Resting HR
- 70 bpm
Daily log: GI score 75, nutritional resilience 32, adherence 61.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02409 | 35% | S01 | SC-12 | no change | 54 |
| P-02018 | 34% | S01 | GI-04 | improved | 46 |
| P-02054 | 32% | S01 | CR-01 | improved | 57 |
| P-02410 | 29% | S01 | GI-04 | improved | 55 |
| P-02307 | 21% | S01 | — | — | 55 |
| P-02598 | 21% | S01 | — | — | 53 |
| P-02550 | 20% | S01 | — | — | 70 |
| P-02276 | 19% | S01 | — | — | 57 |
| P-02437 | 19% | S01 | — | — | 64 |
| P-02041 | 18% | S01 | — | — | 27 |
| P-02087 | 18% | S01 | BR-03 | no change | 40 |
| P-02138 | 18% | S01 | — | — | 79 |