Patient P-02465
Therapy response
Declining
Tolerance
Favorable
GI state
Favorable
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
19%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S04
- Day 108 BR-03 recommended — Behavioural Recommendation BR-03
- Day 109 Patient declined — Not now
- Day 127 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 127.
Primary contributors, last 14 days
- Inflammatory activity+5
- Nutritional resilience-5
- Treatment adherence-5
- Toxicity+3
What helped?
- Behavioural Recommendation BR-03Day 108Declined by patient
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓40
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.5 · butyrate capacity 77/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 54 ms
- Sleep
- 6.5 h
- Steps
- 9,015
- Resting HR
- 65 bpm
Daily log: GI score 21, nutritional resilience 61, adherence 84.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02412 | 48% | S18 | — | — | 52 |
| P-02087 | 46% | S01 | BR-03 | no change | 40 |
| P-02267 | 46% | S09 | BR-03 | no change | 45 |
| P-02010 | 45% | S19 | — | — | 61 |
| P-02280 | 45% | S07 | BR-03 | no change | 50 |
| P-02071 | 44% | S19 | — | — | 52 |
| P-02112 | 43% | S14 | — | — | 42 |
| P-02324 | 43% | S04 | — | — | 57 |
| P-02477 | 43% | S16 | — | — | 53 |
| P-02638 | 43% | S01 | BR-03 | improved | 41 |
| P-02685 | 43% | S16 | DT-01 | improved | 47 |
| P-02239 | 42% | S04 | — | — | 50 |