Patient P-02472
Therapy response
Improving
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
73%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 118 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 118.
Primary contributors, last 14 days
- Inflammatory activity-5
- Nutritional resilience+5
- Toxicity-4
- Treatment adherence-3
- GI instability+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
78%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 89% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 39/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 72 and rising
- WearableSleep 5.7 h, below personal baseline
- Autonomic recovery ↓45
- WearableResting HR 77 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 43
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3 · butyrate capacity 39/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 48 ms
- Sleep
- 5.4 h
- Steps
- 7,356
- Resting HR
- 76 bpm
Daily log: GI score 72, nutritional resilience 35, adherence 66.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02025 | 47% | S15 | CR-01 | improved | 61 |
| P-02165 | 41% | S14 | ME-01 | improved | 59 |
| P-02054 | 39% | S01 | CR-01 | improved | 57 |
| P-02151 | 39% | S04 | CR-01 | improved | 49 |
| P-02316 | 39% | S14 | GI-04 | improved | 51 |
| P-02398 | 39% | S06 | GI-04 | improved | 63 |
| P-02348 | 38% | S14 | GI-04 | improved | 49 |
| P-02401 | 38% | S14 | GI-04 | improved | 49 |
| P-02628 | 37% | S14 | SC-12 | improved | 47 |
| P-02018 | 36% | S01 | GI-04 | improved | 46 |
| P-02094 | 36% | S14 | NP-02 | improved | 53 |
| P-02320 | 36% | S14 | NP-02 | improved | 50 |