Patient P-02506
Synthetic patientMETA-24 · Day 172 · 45–54 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Unstable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 68 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 71 SC-12 recommended — Supportive Compound SC-12
- Day 72 GI-04 recommended — GI Support Protocol GI-04
- Day 72 Patient accepted — Started SC-12 in the companion
- Day 73 Patient declined — Not now
- Day 78 No meaningful change — Supportive Compound SC-12
- Day 86 ME-01 recommended — Monitoring Escalation ME-01
- Day 87 Patient accepted — Started ME-01 in the companion
- Day 90 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 68.
Primary contributors, last 14 days
- GI instability+6
- Nutritional resilience-5
- Toxicity-4
- Treatment adherence+2
What helped?
- Supportive Compound SC-12Day 71Result: no meaningful change
- GI Support Protocol GI-04Day 72Declined by patient
- Monitoring Escalation ME-01Day 86Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable5 min
worsening · -1.7 vs previous 14 d
Sleep duration
Wearable6.9 h
stable · -0.3 vs previous 14 d
Energy level
Daily log1.6/10
stable · +0.1 vs previous 14 d
Steps
Wearable523
worsening · -217 vs previous 14 d
GI burden
Companion64.6/100
stable · -2.0 vs previous 14 d
Adherence
Companion47.8 %
stable · +1.0 vs previous 14 d
Sleep quality
Wearable32/100
worsening · -2.4 vs previous 14 d
Glucose, CGM daily mean
CGM151 mg/dL
stable · +0.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 11 from the failing basin, 77 from restoration.
Would help
- GI-04 GI Support Protocol76% improved among 66 similar · onset 8 d · confidence 95%
- NP-02 Dietary Support Protocol59% improved among 32 similar · onset 10 d · confidence 72%
- CR-01 Clinician Review100% improved among 6 similar · onset 5 d · confidence 72%
- More proteinGI -4.5 next day on high-intake days · n 21
Would not help
- SC-12 Supportive Compoundalready tried, no meaningful change
- Keep histamine lowGI +4.2 next day on high-intake days · n 20
- Keep fat lowGI +4.1 next day on high-intake days · n 18
- Keep ultra-processed lowGI +4.1 next day on high-intake days · n 21
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.5supporter · 95%
- Histamine load+4.2detractor · 95%
- Dietary fat load+4.1detractor · 95%
- Ultra-processed food+4.1detractor · 95%
- Simple carbohydrates+3.8detractor · 95%
- Insoluble fibre+3.2detractor · 81%
- Caffeine+0.3no signal · 15%
- Alcohol-0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 63
- WearableHRV 28 ms, trending down
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 65 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 43/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 77 bpm
- Wearable523 steps/day
- Drug metabolism and exposure ↑20
- BloodToxicity index 55
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.2 · butyrate capacity 43/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 32 ms
- Sleep
- 7.1 h
- Steps
- 1,295
- Resting HR
- 73 bpm
Daily log: GI score 65, nutritional resilience 33, adherence 48.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02132 | 53% | S14 | SC-12 | improved | 40 |
| P-02124 | 50% | S14 | GI-04 | no change | 31 |
| P-02224 | 50% | S14 | NP-02 | no change | 33 |
| P-02253 | 48% | S14 | NP-02 | no change | 41 |
| P-02348 | 48% | S14 | GI-04 | improved | 49 |
| P-02542 | 48% | S14 | NP-02 | improved | 44 |
| P-02574 | 48% | S14 | ME-01 | improved | 45 |
| P-02648 | 48% | S14 | SC-12 | improved | 47 |
| P-02268 | 47% | S14 | GI-04 | improved | 43 |
| P-02505 | 47% | S14 | NP-02 | improved | 45 |
| P-02693 | 47% | S14 | ME-01 | improved | 41 |
| P-02057 | 46% | S14 | GI-04 | improved | 47 |