Patient P-02591
Therapy response
Improving
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Unstable
Discontinuation risk
55%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S13
- Day 10 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 10.
Primary contributors, last 14 days
- Toxicity-15
- GI instability-13
- Inflammatory activity-13
- Nutritional resilience+9
- Treatment adherence-4
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
61%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 89% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable48 min
stable · +0.3 vs previous 14 d
Sleep duration
Wearable6.1 h
stable · +0.2 vs previous 14 d
Energy level
Daily log3.6/10
stable · +0.1 vs previous 14 d
Steps
Wearable5,142
stable · +70 vs previous 14 d
GI burden
Companion53.6/100
improving · -6.3 vs previous 14 d
Adherence
Companion64.2 %
worsening · -6.1 vs previous 14 d
Sleep quality
Wearable26.5/100
improving · +5.6 vs previous 14 d
Glucose, CGM daily mean
CGM140 mg/dL
stable · -1.2 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →Heading towards restoration · 49 from the failing basin, 48 from restoration.
Good elements to keep
- Protein (supports)perturbation · steering +10.6
- Proteinsupporter · GI -6.4 next day
Main detractors to watch
- Low butyrate capacityhidden · steering -17.5
- Dietary fat loadperturbation · steering -11.1
- Alcoholperturbation · steering -10.3
- Low microbial diversityhidden · steering -7.7
- Dietary fat loaddetractor · GI +6.5 next day
- Alcoholdetractor · GI +5.4 next day
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+6.5detractor · 95%
- Protein-6.4supporter · 95%
- Alcohol+5.4detractor · 95%
- Simple carbohydrates+4.4detractor · 95%
- Ultra-processed food+4.3detractor · 95%
- Caffeine+1.6no signal · 34%
- Histamine load+0.5no signal · 15%
- Insoluble fibre0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 54 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 38/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Inflammatory signalling ↓40
- BloodInflammatory load index 53
- WearableHRV 25 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 54
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.7 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 20 ms
- Sleep
- 6.2 h
- Steps
- 4,930
- Resting HR
- 82 bpm
Daily log: GI score 54, nutritional resilience 39, adherence 64.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02054 | 43% | S01 | CR-01 | improved | 57 |
| P-02409 | 35% | S01 | SC-12 | no change | 54 |
| P-02018 | 32% | S01 | GI-04 | improved | 46 |
| P-02410 | 31% | S01 | GI-04 | improved | 55 |
| P-02307 | 23% | S01 | — | — | 55 |
| P-02550 | 23% | S01 | — | — | 70 |
| P-02598 | 23% | S01 | — | — | 53 |
| P-02276 | 21% | S01 | — | — | 57 |
| P-02437 | 21% | S01 | — | — | 64 |
| P-02568 | 21% | S01 | — | — | 51 |
| P-02138 | 20% | S01 | — | — | 79 |
| P-02217 | 20% | S01 | — | — | 61 |