Patient P-02595
Therapy response
Declining
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
71%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S02
- Day 46 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 46.
Primary contributors, last 14 days
- Toxicity+28
- Inflammatory activity+19
- Nutritional resilience-15
- Treatment adherence-10
- GI instability+8
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
68%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 89% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable27 min
worsening · -10.6 vs previous 14 d
Sleep duration
Wearable5.2 h
worsening · -0.4 vs previous 14 d
Energy level
Daily log1.5/10
worsening · -1.1 vs previous 14 d
Steps
Wearable3,567
worsening · -1,354 vs previous 14 d
GI burden
Companion62.5/100
worsening · +13.5 vs previous 14 d
Adherence
Companion69.4 %
worsening · -14.1 vs previous 14 d
Sleep quality
Wearable10.9/100
worsening · -12.9 vs previous 14 d
Glucose, CGM daily mean
CGM147 mg/dL
stable · +5.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 29 from the failing basin, 70 from restoration.
Would help
- GI-04 GI Support Protocol77% improved among 65 similar · onset 8 d · confidence 63%
- ME-01 Monitoring Escalation100% improved among 42 similar · onset 3 d · confidence 73%
- NP-02 Dietary Support Protocol59% improved among 32 similar · onset 10 d · confidence 73%
- More proteinGI -4 next day on high-intake days · n 15
- More histamineGI -2.2 next day on high-intake days · n 17
Would not help
- Keep fat lowGI +3.5 next day on high-intake days · n 20
- Keep simple carbs lowGI +3.3 next day on high-intake days · n 21
- Keep caffeine lowGI +3 next day on high-intake days · n 27
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4supporter · 95%
- Dietary fat load+3.5detractor · 95%
- Simple carbohydrates+3.3detractor · 95%
- Caffeine+3detractor · 95%
- Ultra-processed food+2.6detractor · 93%
- Histamine load-2.2supporter · 59%
- Insoluble fibre+0.7no signal · 23%
- Alcohol-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Autonomic recovery ↓65
- WearableResting HR 80 bpm
- Wearable3,567 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 63 and rising
- WearableSleep 5.2 h, below personal baseline
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 63
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 25/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑40
- BloodInflammatory load index 69
- WearableHRV 27 ms, trending down
DNA
Fictional pharmacogenomic panel
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.7 · butyrate capacity 25/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 33 ms
- Sleep
- 5.4 h
- Steps
- 4,951
- Resting HR
- 78 bpm
Daily log: GI score 63, nutritional resilience 34, adherence 69.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02054 | 36% | S01 | CR-01 | improved | 57 |
| P-02409 | 35% | S01 | SC-12 | no change | 54 |
| P-02018 | 34% | S01 | GI-04 | improved | 46 |
| P-02410 | 29% | S01 | GI-04 | improved | 55 |
| P-02598 | 24% | S01 | — | — | 53 |
| P-02307 | 23% | S01 | — | — | 55 |
| P-02276 | 22% | S01 | — | — | 57 |
| P-02437 | 22% | S01 | — | — | 64 |
| P-02550 | 22% | S01 | — | — | 70 |
| P-02568 | 21% | S01 | — | — | 51 |
| P-02041 | 20% | S01 | — | — | 27 |
| P-02087 | 20% | S01 | BR-03 | no change | 40 |