Patient P-02653

Synthetic patientMETA-24 · Day 180 · 45–54 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Improving

GI state

Deteriorating

Inflammatory state

Favorable

Nutritional resilience

Favorable

Discontinuation risk

27%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 23 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 23.

Primary contributors, last 14 days

Treatment adherence-11
Toxicity-10
GI instability+6
Nutritional resilience+2

What helped?

No interventions yet.

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

32 min

stable · +1.1 vs previous 14 d

Sleep duration

Wearable

6.4 h

stable · +0.0 vs previous 14 d

Energy level

Daily log

7.1/10

improving · +0.5 vs previous 14 d

Steps

Wearable

4,365

improving · +318 vs previous 14 d

GI burden

Companion

19.3/100

stable · -0.6 vs previous 14 d

Adherence

Companion

88.5 %

worsening · -4.9 vs previous 14 d

Sleep quality

Wearable

46.3/100

stable · +0.6 vs previous 14 d

Glucose, CGM daily mean

CGM

137 mg/dL

stable · +1.3 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 94 from the failing basin, 14 from restoration.

Good elements to keep

Butyrate producers intact
hidden · steering +7.5
Protein (supports)
perturbation · steering +5.2
Daily walks resumed
perturbation · steering +3.3
Protein
supporter · GI -2.8 next day

Main detractors to watch

Poor metabolizer
hidden · steering -12.7
FUT2 non-secretor
hidden · steering -10.6
Enterobacteriaceae elevated
hidden · steering -7.4
IL6 high-expression variant
hidden · steering -7.3
Caffeine
detractor · GI +3.8 next day
Histamine load
detractor · GI +3.7 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Caffeine
+3.8detractor · 95%
Histamine load
+3.7detractor · 95%
Ultra-processed food
+3.2detractor · 95%
Protein
-2.8supporter · 95%
Simple carbohydrates
+0.4no signal · 15%
Insoluble fibre
-0.3no signal · 15%
Dietary fat load
-0.1no signal · 15%
Alcohol
+0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Inflammatory signalling ↓25
- DNAIL6 -174 variant raises baseline inflammatory tone
Autonomic recovery ↑20
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Poor metabolizer
Higher exposure at standard dose
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3 · butyrate capacity 75/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 69 ms
Sleep: 6.5 h
Steps: 4,865
Resting HR: 71 bpm

Daily log: GI score 19, nutritional resilience 69, adherence 89.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Keep fibre steady; no new sources this week
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02277	40%	S05	AD-05	improved	92
P-02555	36%	S01	AD-05	no change	79
P-02013	37%	S14	BR-03	no change	94
P-02282	37%	S01	BR-03	no change	88
P-02193	32%	S11	CR-01	improved	87
P-02354	28%	S01	CR-01	improved	78
P-02337	43%	S18	DT-01	no change	100
P-02565	38%	S09	DT-01	no change	79
P-02249	35%	S09	DT-01	improved	100
P-02081	34%	S20	DT-01	no change	88
P-02462	29%	S12	DT-01	improved	65
P-02218	28%	S01	DT-01	improved	61