Patient P-02657
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Improving
Nutritional resilience
Unstable
Discontinuation risk
94%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 72 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 72.
Primary contributors, last 14 days
- Toxicity-14
- Inflammatory activity-13
- Nutritional resilience+13
- GI instability-10
- Treatment adherence+3
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 87% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 66 and rising
- WearableSleep 6.0 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 24/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 73 bpm
- WearableShort sleep window
- Inflammatory signalling ↓25
- BloodInflammatory load index 58
- Drug metabolism and exposure ↑20
- BloodToxicity index 43
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.1 · butyrate capacity 24/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 44 ms
- Sleep
- 5.5 h
- Steps
- 2,777
- Resting HR
- 75 bpm
Daily log: GI score 66, nutritional resilience 38, adherence 42.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02253 | 54% | S14 | NP-02 | no change | 41 |
| P-02628 | 54% | S14 | SC-12 | improved | 47 |
| P-02535 | 52% | S14 | SC-12 | improved | 50 |
| P-02546 | 52% | S20 | NP-02 | improved | 40 |
| P-02516 | 51% | S14 | SC-12 | improved | 51 |
| P-02039 | 50% | S14 | — | — | 38 |
| P-02059 | 49% | S03 | SC-12 | improved | 41 |
| P-02320 | 49% | S14 | NP-02 | improved | 50 |
| P-02340 | 49% | S14 | NP-02 | no change | 46 |
| P-02348 | 49% | S14 | GI-04 | improved | 49 |
| P-02670 | 48% | S14 | SC-12 | improved | 45 |
| P-02316 | 47% | S14 | GI-04 | improved | 51 |