Patient P-02659
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
73%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S09
- Day 23 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 23.
Primary contributors, last 14 days
- Inflammatory activity+26
- GI instability+23
- Toxicity+17
- Nutritional resilience-14
- Treatment adherence-7
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
59%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 56 and rising
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 25/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑25
- BloodInflammatory load index 55
- Autonomic recovery ↓25
- WearableResting HR 77 bpm
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Rapid metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
Microbiome
Shannon diversity 2.7 · butyrate capacity 25/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 56 ms
- Sleep
- 7.4 h
- Steps
- 7,872
- Resting HR
- 73 bpm
Daily log: GI score 56, nutritional resilience 44, adherence 81.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02309 | 52% | S09 | — | — | 67 |
| P-02252 | 50% | S02 | — | — | 65 |
| P-02078 | 39% | S04 | — | — | 56 |
| P-02229 | 39% | S20 | — | — | 56 |
| P-02233 | 37% | S16 | CR-01 | improved | 66 |
| P-02321 | 37% | S17 | GI-04 | improved | 54 |
| P-02009 | 36% | S08 | CR-01 | improved | 64 |
| P-02115 | 34% | S14 | GI-04 | improved | 75 |
| P-02134 | 33% | S11 | — | — | 62 |
| P-02287 | 33% | S03 | NP-02 | no change | 59 |
| P-02298 | 33% | S14 | GI-04 | improved | 65 |
| P-02420 | 33% | S15 | — | — | 54 |