Patient P-01310
Therapy response
Stable
Tolerance
Stable
GI state
Stable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
53%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S01
- Day 80 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 80.
Primary contributors, last 14 days
- Treatment adherence+5
- Inflammatory activity+4
- Toxicity-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion53.2/100
worsening · +6.3 vs previous 14 d
Toxicity
Blood56.9/100
stable · +0.5 vs previous 14 d
Sleep quality
Wearable23.6/100
worsening · -3.8 vs previous 14 d
Energy level
Daily log2.9/10
worsening · -0.5 vs previous 14 d
Stress level
Daily log6.4/10
worsening · +0.4 vs previous 14 d
Steps
Wearable6,922
worsening · -478 vs previous 14 d
Adherence
Companion71.7 %
worsening · -6.7 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 37 from the failing basin, 56 from restoration.
Would help
Would not help
- Keep alcohol lowGI +3.2 next day on high-intake days · n 24
- Keep histamine lowGI +3 next day on high-intake days · n 25
- Keep fat lowGI +2.7 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Alcohol+3.2detractor · 95%
- Histamine load+3detractor · 95%
- Dietary fat load+2.7detractor · 95%
- Spicy / capsaicin+0.6no signal · 16%
- Simple carbohydrates+0.4no signal · 15%
- Insoluble fibre+0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
- WearableSleep 6.0 h, below personal baseline
- Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- WearableHRV 33 ms, trending down
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 44/100
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑20
- BloodToxicity index 57
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.1 · butyrate capacity 44/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 27 ms
- Sleep
- 5.7 h
- Steps
- 6,945
- Resting HR
- 72 bpm
Daily log: GI score 53, nutritional resilience 39, adherence 72.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01877 | 42% | S01 | CR-01 | improved | 67 |
| P-01327 | 32% | S01 | GI-04 | improved | 56 |
| P-01688 | 32% | S01 | GI-04 | improved | 40 |
| P-01813 | 29% | S01 | NP-02 | no change | 40 |
| P-01604 | 24% | S01 | — | — | 71 |
| P-01821 | 23% | S01 | — | — | 58 |
| P-01823 | 23% | S01 | — | — | 57 |
| P-01459 | 41% | S02 | — | — | 51 |
| P-01635 | 35% | S02 | GI-04 | improved | 49 |
| P-01452 | 34% | S02 | GI-04 | improved | 46 |
| P-01498 | 24% | S02 | — | — | 56 |
| P-01499 | 23% | S02 | — | — | 65 |