Patient P-01325
Therapy response
Improving
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
49%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S16
- Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 56 GI-04 recommended — GI Support Protocol GI-04
- Day 57 Patient accepted — Started GI-04 in the companion
- Day 65 GI symptom burden −39% vs expected — GI Support Protocol GI-04
- Day 71 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 47.
Primary contributors, last 14 days
- Toxicity+10
- GI instability-4
- Inflammatory activity+3
- Treatment adherence-2
What helped?
- GI Support Protocol GI-04Day 56Result: symptom burden −39%
LIFE OS recommendation
Dietary Support Protocol NP-02
51%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion41.5/100
worsening · +4.1 vs previous 14 d
Toxicity
Blood49.4/100
worsening · +1.9 vs previous 14 d
Sleep quality
Wearable24.7/100
stable · +0.2 vs previous 14 d
Energy level
Daily log3.9/10
worsening · -0.6 vs previous 14 d
Stress level
Daily log6.2/10
stable · +0.1 vs previous 14 d
Steps
Wearable3,607
worsening · -189 vs previous 14 d
Adherence
Companion56.9 %
worsening · -14.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 43 from the failing basin, 45 from restoration.
Would help
Would not help
- Keep fat lowGI +3.5 next day on high-intake days · n 26
- Keep simple carbs lowGI +2.8 next day on high-intake days · n 20
- Keep histamine lowGI +2.4 next day on high-intake days · n 17
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+3.5detractor · 95%
- Simple carbohydrates+2.8detractor · 89%
- Histamine load+2.4detractor · 82%
- Alcohol+2.2detractor · 66%
- Spicy / capsaicin+1.7no signal · 51%
- Insoluble fibre-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 30/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 51
- WearableHRV 23 ms, trending down
- Autonomic recovery ↑65
- WearableResting HR 73 bpm
- Wearable3,607 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 49
- Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.3 · butyrate capacity 30/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 25 ms
- Sleep
- 5.9 h
- Steps
- 3,495
- Resting HR
- 73 bpm
Daily log: GI score 42, nutritional resilience 41, adherence 57.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01804 | 26% | S19 | AD-05 | improved | 61 |
| P-01442 | 34% | S13 | CR-01 | improved | 61 |
| P-01696 | 34% | S20 | CR-01 | improved | 59 |
| P-01371 | 33% | S06 | CR-01 | improved | 63 |
| P-01835 | 31% | S17 | CR-01 | improved | 56 |
| P-01708 | 30% | S07 | CR-01 | improved | 59 |
| P-01388 | 29% | S17 | CR-01 | improved | 59 |
| P-01877 | 27% | S01 | CR-01 | improved | 67 |
| P-01430 | 25% | S05 | CR-01 | improved | 54 |
| P-01767 | 24% | S14 | DT-01 | no change | 63 |
| P-01667 | 47% | S10 | GI-04 | improved | 49 |
| P-01341 | 46% | S14 | GI-04 | improved | 47 |