Patient P-01356

Synthetic patientNBL-101 · Day 116 · 45–54 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Improving

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Unstable

Discontinuation risk

66%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 52 SC-12 recommended — Supportive Compound SC-12
Day 53 Patient accepted — Started SC-12 in the companion
Day 59 No meaningful change — Supportive Compound SC-12
Day 60 GI-04 recommended — GI Support Protocol GI-04
Day 61 Patient accepted — Started GI-04 in the companion
Day 69 GI symptom burden −21% vs expected — GI Support Protocol GI-04
Day 75 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 49.

Primary contributors, last 14 days

Toxicity-11
Nutritional resilience-7
GI instability+4
Treatment adherence-4

What helped?

Supportive Compound SC-12Day 52
Result: no meaningful change
GI Support Protocol GI-04Day 60
Result: symptom burden −21%

LIFE OS recommendation

Dietary Support Protocol NP-02

59%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

47.8/100

stable · +1.5 vs previous 14 d

Toxicity

Blood

37.5/100

improving · -2.2 vs previous 14 d

Sleep quality

Wearable

38.1/100

stable · -0.7 vs previous 14 d

Energy level

Daily log

2.8/10

worsening · -0.3 vs previous 14 d

Stress level

Daily log

4.7/10

stable · -0.0 vs previous 14 d

Steps

Wearable

2,806

improving · +251 vs previous 14 d

Adherence

Companion

48 %

stable · +0.4 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 34 from the failing basin, 53 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 78 similar · onset 3 d · confidence 71%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 71%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 71%

Would not help

SC-12 Supportive Compound
already tried, no meaningful change
Keep fibre low
GI +3.8 next day on high-intake days · n 19
Keep fat low
GI +3.7 next day on high-intake days · n 13
Keep spicy low
GI +2.8 next day on high-intake days · n 14

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Insoluble fibre
+3.8detractor · 95%
Dietary fat load
+3.7detractor · 95%
Spicy / capsaicin
+2.8detractor · 75%
Histamine load
+1.7no signal · 39%
Alcohol
+0.8no signal · 15%
Simple carbohydrates
+0.2no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 48 and rising
- WearableSleep 5.7 h, below personal baseline
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 24/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 47
Autonomic recovery ↓40
- Wearable2,806 steps/day
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3 · butyrate capacity 24/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 55 ms
Sleep: 5.9 h
Steps: 2,783
Resting HR: 70 bpm

Daily log: GI score 48, nutritional resilience 39, adherence 48.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01389	60%	S14	SC-12	improved	46
P-01505	56%	S14	NP-02	improved	41
P-01458	55%	S14	GI-04	improved	44
P-01365	53%	S14	SC-12	improved	49
P-01413	53%	S14	GI-04	improved	44
P-01781	53%	S14	NP-02	improved	45
P-01436	52%	S14	GI-04	improved	38
P-01559	52%	S06	GI-04	improved	42
P-01307	51%	S14	GI-04	improved	43
P-01556	50%	S14	GI-04	improved	44
P-01616	50%	S14	GI-04	improved	39
P-01486	49%	S18	GI-04	improved	47