Patient P-01376

Synthetic patientNBL-101 · Day 95 · 55–64 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Improving

GI state

Deteriorating

Inflammatory state

Stable

Nutritional resilience

Stable

Discontinuation risk

70%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 55 GI-04 recommended — GI Support Protocol GI-04
Day 56 Patient accepted — Started GI-04 in the companion
Day 64 GI symptom burden −39% vs expected — GI Support Protocol GI-04
Day 70 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 45.

Primary contributors, last 14 days

Toxicity-10
GI instability+8
Treatment adherence-3

What helped?

GI Support Protocol GI-04Day 55
Result: symptom burden −39%

LIFE OS recommendation

Dietary Support Protocol NP-02

58%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

53.4/100

improving · -2.4 vs previous 14 d

Toxicity

Blood

28.9/100

worsening · +5.4 vs previous 14 d

Sleep quality

Wearable

34.1/100

worsening · -1.9 vs previous 14 d

Energy level

Daily log

4.4/10

worsening · -0.3 vs previous 14 d

Stress level

Daily log

6.2/10

stable · +0.2 vs previous 14 d

Steps

Wearable

6,828

stable · +39 vs previous 14 d

Adherence

Companion

49.5 %

worsening · -11.9 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 42 from the failing basin, 48 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 70%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 70%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 70%

Would not help

Keep histamine low
GI +4.8 next day on high-intake days · n 18
Keep fat low
GI +4.4 next day on high-intake days · n 21
Keep simple carbs low
GI +3.1 next day on high-intake days · n 14

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+4.8detractor · 95%
Dietary fat load
+4.4detractor · 95%
Simple carbohydrates
+3.1detractor · 84%
Alcohol
+2.6detractor · 70%
Spicy / capsaicin
-0.4no signal · 15%
Insoluble fibre
+0.2no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 41/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 43
Autonomic recovery ↓45
- WearableResting HR 73 bpm
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.3 · butyrate capacity 41/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 41 ms
Sleep: 6.3 h
Steps: 7,105
Resting HR: 74 bpm

Daily log: GI score 53, nutritional resilience 46, adherence 50.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01327	43%	S01	GI-04	improved	56
P-01688	36%	S01	GI-04	improved	40
P-01813	30%	S01	NP-02	no change	40
P-01310	29%	S01	—	—	57
P-01821	26%	S01	—	—	58
P-01877	26%	S01	CR-01	improved	67
P-01823	25%	S01	—	—	57
P-01604	24%	S01	—	—	71
P-01452	39%	S02	GI-04	improved	46
P-01635	38%	S02	GI-04	improved	49
P-01459	30%	S02	—	—	51
P-01498	25%	S02	—	—	56