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Patient P-01381

Synthetic patientNBL-101 · Day 108 · 75+ · M · baseline S12Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Favorable
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Favorable
Discontinuation risk
10%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S12
  2. Day 10 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 10.

Primary contributors, last 14 days
  • Inflammatory activity-14
  • GI instability-9
  • Treatment adherence+6
  • Toxicity-3
  • Nutritional resilience+2

What helped?

No interventions yet.

    LIFE OS recommendation
    No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    18.3/100
    improving · -6.5 vs previous 14 d
    Toxicity
    Blood
    11.3/100
    worsening · +4.0 vs previous 14 d
    Sleep quality
    Wearable
    46.5/100
    improving · +4.0 vs previous 14 d
    Energy level
    Daily log
    6.3/10
    improving · +0.3 vs previous 14 d
    Stress level
    Daily log
    3.7/10
    improving · -0.3 vs previous 14 d
    Steps
    Wearable
    4,274
    stable · -58 vs previous 14 d
    Adherence
    Companion
    94.6 %
    stable · -1.9 vs previous 14 d
    This trajectory is doing well — what to keep, what to watch
    Steering view →

    Heading towards restoration · 85 from the failing basin, 12 from restoration.

    Good elements to keep
    • Daily walks resumed
      perturbation · steering +3.3
    Main detractors to watch
    • Low butyrate capacity
      hidden · steering -17.5
    • Poor metabolizer
      hidden · steering -12.7
    • FUT2 non-secretor
      hidden · steering -10.6
    • Histamine load
      perturbation · steering -8.1
    • Histamine load
      detractor · GI +4.3 next day
    • Dietary fat load
      detractor · GI +4.1 next day
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +4.3detractor · 95%
    • Dietary fat load
      +4.1detractor · 95%
    • Simple carbohydrates
      +3.8detractor · 95%
    • Spicy / capsaicin
      +3.4detractor · 89%
    • Alcohol
      -0.9no signal · 20%
    • Insoluble fibre
      -0.7no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Mucosal barrier integrity ↓60
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • MicrobiomeAkkermansia low → thinner mucus layer
    • Drug metabolism and exposure ↑40
      • DNACYP2D6 poor metabolizer → higher exposure
    • Butyrate / short-chain fatty acid production ↓35
      • MicrobiomeButyrate capacity 44/100
    • Inflammatory signalling ↓25
      • DNAIL6 -174 variant raises baseline inflammatory tone
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • IL6 -174 G/C
      Higher inflammatory tone
    • CYP2D6 Poor metabolizer
      Higher exposure at standard dose
    Microbiome
    Shannon diversity 2.5 · butyrate capacity 44/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisNormal
    • Bifidobacterium longumLow
    • EnterobacteriaceaeHigh
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    34 ms
    Sleep
    6.4 h
    Steps
    3,800
    Resting HR
    63 bpm
    Daily log: GI score 18, nutritional resilience 66, adherence 95.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • A 15-minute walk after lunch
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
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    P-0134644%S12DT-01improved52
    P-0159344%S10HY-01improved56
    P-0145540%S01GI-04improved61
    P-0155540%S06GI-04improved56
    P-0172439%S10DT-01improved63
    P-0134238%S11DT-01improved48
    P-0175238%S20DT-01improved50
    P-0186138%S12HY-01improved47
    P-0143037%S05CR-01improved54
    P-0157136%S13SC-12improved57
    P-0180436%S19AD-05improved61
    P-0137435%S08HY-01improved49