Patient P-01555

Synthetic patientNBL-101 · Day 100 · 35–44 · F · baseline S06Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Favorable

Inflammatory state

Favorable

Nutritional resilience

Improving

Discontinuation risk

12%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S06
Day 10 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 14 GI-04 recommended — GI Support Protocol GI-04
Day 15 Patient accepted — Started GI-04 in the companion
Day 23 GI symptom burden −20% vs expected — GI Support Protocol GI-04
Day 29 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 10.

Primary contributors, last 14 days

Toxicity-7
Nutritional resilience+4
GI instability+3
Treatment adherence-3
Inflammatory activity-2

What helped?

GI Support Protocol GI-04Day 14
Result: symptom burden −20%

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients.

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 41/100
- MicrobiomeF. prausnitzii depleted
Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
Autonomic recovery ↓20
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Intermediate metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.3 · butyrate capacity 41/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 69 ms
Sleep: 6.6 h
Steps: 6,498
Resting HR: 70 bpm

Daily log: GI score 19, nutritional resilience 70, adherence 95.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01666	55%	S03	—	—	55
P-01385	54%	S06	HY-01	improved	50
P-01522	52%	S06	DT-01	no change	62
P-01333	50%	S06	—	—	48
P-01633	50%	S16	GI-04	no change	55
P-01861	49%	S12	HY-01	improved	47
P-01374	48%	S08	HY-01	improved	49
P-01609	47%	S12	GI-04	no change	48
P-01752	46%	S20	DT-01	improved	50
P-01392	45%	S03	—	—	47
P-01513	45%	S19	GI-04	no change	53
P-01820	45%	S17	—	—	53