Patient P-01383

Synthetic patientNBL-101 · Day 117 · 35–44 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Deteriorating

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Declining

Discontinuation risk

64%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −28% vs expected — Dietary Support Protocol NP-02
Day 46 SC-12 recommended — Supportive Compound SC-12
Day 47 Patient accepted — Started SC-12 in the companion
Day 48 Tolerance state changed — Unstable → Improving
Day 53 GI symptom burden −21% vs expected — Supportive Compound SC-12
Day 54 GI-04 recommended — GI Support Protocol GI-04
Day 55 Patient accepted — Started GI-04 in the companion
Day 58 ME-01 recommended — Monitoring Escalation ME-01
Day 59 Tolerance state changed — Unstable → Improving
Day 59 Patient accepted — Started ME-01 in the companion
Day 62 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
Day 63 GI symptom burden −23% vs expected — GI Support Protocol GI-04
Day 69 Tolerance state changed — Unstable → Improving
Day 112 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 112.

Primary contributors, last 14 days

Nutritional resilience-12
GI instability+10
Toxicity+9
Inflammatory activity+8
Treatment adherence+2

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −28%
Supportive Compound SC-12Day 46
Result: symptom burden −21%
GI Support Protocol GI-04Day 54
Result: symptom burden −23%
Monitoring Escalation ME-01Day 58
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Clinician Review CR-01

81%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 5 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

38.5/100

stable · +0.7 vs previous 14 d

Toxicity

Blood

39.4/100

worsening · +2.6 vs previous 14 d

Sleep quality

Wearable

46/100

stable · +0.2 vs previous 14 d

Energy level

Daily log

4.5/10

worsening · -0.3 vs previous 14 d

Stress level

Daily log

5.8/10

stable · +0.1 vs previous 14 d

Steps

Wearable

4,593

worsening · -163 vs previous 14 d

Adherence

Companion

61.6 %

stable · +2.3 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 43 from the failing basin, 47 from restoration.

Would help

CR-01 Clinician Review
100% improved among 6 similar · onset 5 d · confidence 69%

Would not help

Keep fat low
GI +2.1 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+2.1detractor · 78%
Simple carbohydrates
+1.4no signal · 52%
Alcohol
-0.6no signal · 20%
Insoluble fibre
+0.5no signal · 17%
Spicy / capsaicin
-0.4no signal · 15%
Histamine load
-0.2no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 41
Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 25/100
- MicrobiomeF. prausnitzii depleted
Autonomic recovery ↓25
- WearableResting HR 79 bpm

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Rapid metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.9 · butyrate capacity 25/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 50 ms
Sleep: 6.7 h
Steps: 3,406
Resting HR: 79 bpm

Daily log: GI score 39, nutritional resilience 52, adherence 62.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01483	32%	S14	AD-05	no change	35
P-01377	31%	S11	AD-05	no change	42
P-01679	31%	S12	AD-05	no change	39
P-01541	29%	S09	AD-05	no change	43
P-01804	28%	S19	AD-05	improved	61
P-01350	31%	S19	BR-03	no change	34
P-01689	30%	S13	BR-03	no change	50
P-01313	27%	S01	BR-03	improved	32
P-01371	32%	S06	CR-01	improved	63
P-01430	31%	S05	CR-01	improved	54
P-01442	31%	S13	CR-01	improved	61
P-01696	31%	S20	CR-01	improved	59