Patient P-01398
Therapy response
Declining
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Stable
Nutritional resilience
Improving
Discontinuation risk
68%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 GI symptom burden −20% vs expected — Dietary Support Protocol NP-02
- Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 48 Tolerance state changed — Unstable → Improving
- Day 54 GI-04 recommended — GI Support Protocol GI-04
- Day 55 Patient accepted — Started GI-04 in the companion
- Day 63 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 47.
Primary contributors, last 14 days
- Nutritional resilience+10
- GI instability-9
- Toxicity+7
- Treatment adherence-2
What helped?
- Dietary Support Protocol NP-02Day 31Result: symptom burden −20%
- GI Support Protocol GI-04Day 54Result: no meaningful change
LIFE OS recommendation
Monitoring Escalation ME-01
80%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 35/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓65
- WearableResting HR 73 bpm
- Wearable2,282 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 53 and rising
- WearableSleep 5.6 h, below personal baseline
- Inflammatory signalling ↑40
- BloodInflammatory load index 55
- WearableHRV 17 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 48
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3 · butyrate capacity 35/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 20 ms
- Sleep
- 5.5 h
- Steps
- 2,677
- Resting HR
- 76 bpm
Daily log: GI score 53, nutritional resilience 47, adherence 50.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01332 | 49% | S14 | NP-02 | improved | 43 |
| P-01554 | 45% | S05 | GI-04 | improved | 47 |
| P-01786 | 45% | S07 | ME-01 | improved | 46 |
| P-01349 | 44% | S14 | GI-04 | improved | 38 |
| P-01409 | 44% | S14 | SC-12 | improved | 41 |
| P-01393 | 42% | S14 | GI-04 | improved | 53 |
| P-01777 | 42% | S14 | SC-12 | improved | 43 |
| P-01872 | 42% | S14 | NP-02 | improved | 47 |
| P-01364 | 41% | S14 | GI-04 | improved | 49 |
| P-01410 | 41% | S14 | GI-04 | no change | 52 |
| P-01429 | 41% | S09 | GI-04 | improved | 45 |
| P-01433 | 41% | S14 | GI-04 | improved | 48 |