Patient P-01777

Synthetic patientNBL-101 · Day 98 · 45–54 · M · baseline S14Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Unstable

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

88%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 47 SC-12 recommended — Supportive Compound SC-12
Day 48 Patient accepted — Started SC-12 in the companion
Day 50 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 54 GI symptom burden −21% vs expected — Supportive Compound SC-12
Day 60 Tolerance state changed — Unstable → Improving
Day 66 ME-01 recommended — Monitoring Escalation ME-01
Day 67 Patient accepted — Started ME-01 in the companion
Day 70 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 50.

Primary contributors, last 14 days

Nutritional resilience+11
Inflammatory activity-9
Toxicity-5
GI instability+3
Treatment adherence-2

What helped?

Supportive Compound SC-12Day 47
Result: symptom burden −21%
Monitoring Escalation ME-01Day 66
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

89%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 58 and rising
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 22/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 47

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.7 · butyrate capacity 22/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 40 ms
Sleep: 6.9 h
Steps: 7,554
Resting HR: 72 bpm

Daily log: GI score 58, nutritional resilience 49, adherence 50.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01494	56%	S14	GI-04	improved	42
P-01782	54%	S14	NP-02	no change	48
P-01409	52%	S14	SC-12	improved	41
P-01834	52%	S14	NP-02	improved	44
P-01891	51%	S14	SC-12	improved	41
P-01709	50%	S14	GI-04	improved	43
P-01595	49%	S14	GI-04	no change	51
P-01603	49%	S14	GI-04	improved	40
P-01781	49%	S14	NP-02	improved	45
P-01360	48%	S14	GI-04	improved	52
P-01429	48%	S09	GI-04	improved	45
P-01843	48%	S14	SC-12	no change	45