Patient P-01400

Synthetic patientNBL-101 · Day 117 · 55–64 · F · baseline S17Open companion preview

Therapy response

Stable

Tolerance

Favorable

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Improving

Discontinuation risk

48%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S17
Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 54 SC-12 recommended — Supportive Compound SC-12
Day 55 Patient accepted — Started SC-12 in the companion
Day 59 GI-04 recommended — GI Support Protocol GI-04
Day 60 Patient accepted — Started GI-04 in the companion
Day 61 GI symptom burden −14% vs expected — Supportive Compound SC-12
Day 67 Tolerance state changed — Unstable → Improving
Day 68 GI symptom burden −32% vs expected — GI Support Protocol GI-04
Day 72 ME-01 recommended — Monitoring Escalation ME-01
Day 73 Patient accepted — Started ME-01 in the companion
Day 74 Tolerance state changed — Unstable → Improving
Day 76 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 45.

Primary contributors, last 14 days

Nutritional resilience+4
Treatment adherence-4
Toxicity-4
GI instability-3

What helped?

Supportive Compound SC-12Day 54
Result: symptom burden −14%
GI Support Protocol GI-04Day 59
Result: symptom burden −32%
Monitoring Escalation ME-01Day 72
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

49%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 46 and rising
Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 45
- WearableHRV 25 ms, trending down
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 41/100
- Daily logFibre intake low in recent food logs

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.2 · butyrate capacity 41/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 24 ms
Sleep: 6.8 h
Steps: 6,833
Resting HR: 71 bpm

Daily log: GI score 46, nutritional resilience 50, adherence 53.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01336	52%	S03	GI-04	improved	51
P-01706	52%	S14	GI-04	improved	55
P-01543	51%	S14	GI-04	improved	54
P-01627	51%	S14	GI-04	improved	54
P-01556	50%	S14	GI-04	improved	44
P-01624	50%	S14	GI-04	improved	52
P-01879	50%	S14	SC-12	improved	51
P-01686	49%	S10	GI-04	improved	43
P-01661	48%	S03	GI-04	improved	52
P-01688	48%	S01	GI-04	improved	40
P-01323	47%	S14	GI-04	improved	50
P-01518	47%	S14	GI-04	improved	40