DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
75/100
vs baseline (day 0)
+12
2 improved · 13 worsened
synthetic signature · consistent with this patient's biology
- 1 opportunist above range: Klebsiella pneumoniae
- 6 keystone species absent
- Shannon 1.84 (expected ≥ 3)
- 12 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 65
Pathogens / opportunists1/5
Keystone species6/8
↑ from 4
Diversity2/2
Metabolic modules0/4
Vitamin synthesis6/7
↑ from 4
Oral translocation1/1
Host DNA1/1
↑ from 0
Tissue recycling1/1
Central mechanisms2/2
↑ from 1
Virulence factors6/6
↑ from 4
Antibiotic resistance genes12/12
↑ from 8
Genetic predisposition2/2
Opportunists above range
Klebsiella pneumoniae 10.192% AR
Keystone species absent
Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum, Eubacterium rectale, Faecalibacterium prausnitzii
Capacity
Shannon 1.84 · butyrate 293 CPM · SCFA 577
6 vitamins below
Host & mechanisms
host DNA fragmentation atypical
tissue recycling 65/100
oral translocation 7.69% AR
molecular_mimicry above
estrobolome above
12 resistance genes · 6 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 0.689 % AR · in range | 0.662 % AR · in range | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 0.051 % AR · in range | 10.192 % AR · above range(worsened) | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 12.189 % AR · above range | 0.246 % AR · in range(improved) | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 0.007 % AR · in range | 0.03 % AR · in range | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 0.036 % AR · in range | 0.035 % AR · in range | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 0.67 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 0.68 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 0.19 % AR · in range | 0.77 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 1.16 % AR · in range | 0.34 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 2.28 · below range | 1.84 · below range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 89 specii · below range | 43 specii · below range | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 452 CPM · in range | 293 CPM · in range | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 827 CPM · in range | 577 CPM · in range | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 247 CPM · in range | 124 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 99 CPM · in range | 97 CPM · in range | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 172 CPM · below range | 282 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 495 CPM · below range | 243 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 480 CPM · below range | 292 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 196 CPM · below range | 308 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 4298 CPM · in range | 533 CPM · below range(worsened) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 3382 CPM · in range | 492 CPM · below range(worsened) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3574 CPM · in range | 2832 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 5.54 % AR · above range | 7.69 % AR · above range | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 167 pb · in range | 238 pb · atypical(worsened) | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 56 /100 · above range | 65 /100 · above range | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 72 /100 · above range | 84 /100 · above range | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 65 /100 · in range | 75 /100 · above range(worsened) | expected < 65 | Estrogen-recycling capacity. |
Species dominance · 1
| Bifidobacterium breve | 32.83 % AR · above range | resolved(resolved) | expected < 20% per specie | One species occupies the niche of others. |
Virulence factors · 6
| fimD outer membrane usher | 96 potriviri/M · present | 99 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 84 potriviri/M · present | 22 potriviri/M · present | expected absent | Virulence factor detected. |
| irp2 yersiniabactin synthetase | 89 potriviri/M · present | 45 potriviri/M · present | expected absent | Virulence factor detected. |
| espX4 type III secretion | 45 potriviri/M · present | 34 potriviri/M · present | expected absent | Virulence factor detected. |
| kpsD polysialic acid transport | — | 22 potriviri/M · present(new) | expected absent | Virulence factor detected. |
| acrB acriflavine resistance | — | 93 potriviri/M · present(new) | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 12
| sul1 | 8 citiri/M · present | 3.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 1.8 citiri/M · present | 3.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 7 citiri/M · present | 6.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 8.9 citiri/M · present | 9.8 citiri/M · present | expected nedetectat | Resistance gene detected. |
| aadA | 1.2 citiri/M · present | 5.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| dfrA1 | 2.7 citiri/M · present | 1.6 citiri/M · present | expected nedetectat | Resistance gene detected. |
| APH(6)-Id | 6.5 citiri/M · present | 7.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Erm(49) | 2.8 citiri/M · present | 8.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| msrC | — | 6.1 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| eptB | — | 10 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| ugd | — | 5.1 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| arnA | — | 1.3 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| FUT2 | 2.13 OR · risk variant | 3.22 OR · risk variant | expected reference genotype | Reduced mucosal fucosylation |
| CYP2D6 | 1.55 OR · risk variant | 2.91 OR · risk variant | expected reference genotype | Expected exposure |