Why does this trajectory go where it goes?
The hidden elements steering this state toward the failing basin or the restoration basin: interventions pull, perturbations push, and the genome and microbiome decide how strongly. Same data as the trajectory chart, read as a control problem.
- No recorded event.
- +0.64
- -0.36
- -0.26
- -0.19
P-01400 is on day 109 of NBL-101 (EC-03, baseline S14): response stable, tolerance deteriorating, GI stable. Over 14 days response moved -2 and GI +4; discontinuation risk is 66%. The state is between basins, heading towards failing, after diverging from the model on day 46.
Biology sets the gain: FUT2 non-secretor, Low butyrate capacity, Low microbial diversity, Baseline state S14, Cluster EC-03 (high response / high intolerance), Adherence < 60%; butyrate capacity 23/100, diversity 1.9. Pushing it down: Low butyrate capacity (-27), Klebsiella pneumoniae 10.192% (LPS load) (-25.4), Alcohol (-22.2). Pulling it up: GI Support Protocol GI-04 (+46.6). From the daily log: alcohol +7 GI next day, fat +6 GI next day, histamine +5.1 GI next day, fibre +3.4 GI next day.
Past actions: GI-04 on day 61 → improved (31%).
Next: AD-05 — 50% of 284 similar trajectories improved, 45% probability here. Adherence is 49% and stable; nothing else works if the dose is missed → adherence support first. This would be contradicted by a further GI rise within the onset window or falling adherence.