Patient P-01406

Synthetic patientNBL-101 · Day 115 · 65–74 · F · baseline S18Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Improving

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Unstable

Discontinuation risk

58%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S18
Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 51 GI-04 recommended — GI Support Protocol GI-04
Day 52 Patient accepted — Started GI-04 in the companion
Day 60 GI symptom burden −35% vs expected — GI Support Protocol GI-04
Day 66 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 48.

Primary contributors, last 14 days

Inflammatory activity+7
Toxicity-7
GI instability+4
Nutritional resilience-3
Treatment adherence+2

What helped?

GI Support Protocol GI-04Day 51
Result: symptom burden −35%

LIFE OS recommendation

Dietary Support Protocol NP-02

56%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

49.4/100

improving · -2.1 vs previous 14 d

Toxicity

Blood

41.2/100

improving · -3.3 vs previous 14 d

Sleep quality

Wearable

36.2/100

stable · -1.0 vs previous 14 d

Energy level

Daily log

4/10

improving · +0.2 vs previous 14 d

Stress level

Daily log

6/10

stable · -0.3 vs previous 14 d

Steps

Wearable

4,141

improving · +562 vs previous 14 d

Adherence

Companion

50.3 %

stable · +1.1 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 36 from the failing basin, 52 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 67%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 67%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 67%

Would not help

Keep histamine low
GI +6.5 next day on high-intake days · n 24
Keep fat low
GI +5.7 next day on high-intake days · n 21
Keep alcohol low
GI +4.9 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+6.5detractor · 95%
Dietary fat load
+5.7detractor · 95%
Alcohol
+4.9detractor · 95%
Simple carbohydrates
+3.6detractor · 84%
Spicy / capsaicin
+1.3no signal · 26%
Insoluble fibre
-1no signal · 22%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 49 and rising
Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 52
- WearableHRV 26 ms, trending down
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 42/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑25
- WearableResting HR 74 bpm
Drug metabolism and exposure ↑20
- BloodToxicity index 41

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.6 · butyrate capacity 42/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 28 ms
Sleep: 6.7 h
Steps: 4,197
Resting HR: 77 bpm

Daily log: GI score 49, nutritional resilience 40, adherence 50.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01804	22%	S19	AD-05	improved	61
P-01696	31%	S20	CR-01	improved	59
P-01708	30%	S07	CR-01	improved	59
P-01371	29%	S06	CR-01	improved	63
P-01388	28%	S17	CR-01	improved	59
P-01442	28%	S13	CR-01	improved	61
P-01835	28%	S17	CR-01	improved	56
P-01877	28%	S01	CR-01	improved	67
P-01430	23%	S05	CR-01	improved	54
P-01342	21%	S11	DT-01	improved	48
P-01661	53%	S03	GI-04	improved	52
P-01327	51%	S01	GI-04	improved	56