Patient P-01412
Therapy response
Improving
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
88%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 GI symptom burden −18% vs expected — Dietary Support Protocol NP-02
- Day 48 Tolerance state changed — Unstable → Improving
- Day 53 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 56 GI-04 recommended — GI Support Protocol GI-04
- Day 57 Patient accepted — Started GI-04 in the companion
- Day 65 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 53.
Primary contributors, last 14 days
- GI instability+10
- Inflammatory activity+6
- Nutritional resilience-5
- Toxicity+5
- Treatment adherence+2
What helped?
- Dietary Support Protocol NP-02Day 31Result: symptom burden −18%
- GI Support Protocol GI-04Day 56Result: no meaningful change
LIFE OS recommendation
Monitoring Escalation ME-01
91%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion66.7/100
worsening · +2.9 vs previous 14 d
Toxicity
Blood50.4/100
worsening · +8.0 vs previous 14 d
Sleep quality
Wearable47/100
improving · +4.2 vs previous 14 d
Energy level
Daily log2.5/10
stable · -0.1 vs previous 14 d
Stress level
Daily log6.1/10
worsening · +0.3 vs previous 14 d
Steps
Wearable6,380
stable · -153 vs previous 14 d
Adherence
Companion48 %
stable · -0.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 27 from the failing basin, 68 from restoration.
Would help
Would not help
- GI-04 GI Support Protocolalready tried, no meaningful change
- Keep histamine lowGI +5.6 next day on high-intake days · n 26
- Keep fat lowGI +5.5 next day on high-intake days · n 22
- Keep alcohol lowGI +5.1 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.6detractor · 95%
- Dietary fat load+5.5detractor · 95%
- Alcohol+5.1detractor · 95%
- Simple carbohydrates+1.2no signal · 24%
- Spicy / capsaicin-0.7no signal · 15%
- Insoluble fibre-0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 67 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 40/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- Autonomic recovery ↓25
- WearableResting HR 74 bpm
- Drug metabolism and exposure ↑20
- BloodToxicity index 50
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3 · butyrate capacity 40/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 49 ms
- Sleep
- 6.8 h
- Steps
- 6,322
- Resting HR
- 73 bpm
Daily log: GI score 67, nutritional resilience 37, adherence 48.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01377 | 19% | S11 | AD-05 | no change | 42 |
| P-01483 | 19% | S14 | AD-05 | no change | 35 |
| P-01689 | 20% | S13 | BR-03 | no change | 50 |
| P-01708 | 35% | S07 | CR-01 | improved | 59 |
| P-01371 | 28% | S06 | CR-01 | improved | 63 |
| P-01388 | 27% | S17 | CR-01 | improved | 59 |
| P-01835 | 27% | S17 | CR-01 | improved | 56 |
| P-01877 | 27% | S01 | CR-01 | improved | 67 |
| P-01696 | 26% | S20 | CR-01 | improved | 59 |
| P-01442 | 24% | S13 | CR-01 | improved | 61 |
| P-01430 | 20% | S05 | CR-01 | improved | 54 |
| P-01342 | 19% | S11 | DT-01 | improved | 48 |