Patient P-01438
Synthetic patientNBL-101 · Day 117 · 45–54 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
61%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 No meaningful change — Dietary Support Protocol NP-02
- Day 46 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 50 GI-04 recommended — GI Support Protocol GI-04
- Day 51 Patient accepted — Started GI-04 in the companion
- Day 59 GI symptom burden −32% vs expected — GI Support Protocol GI-04
- Day 65 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 46.
Primary contributors, last 14 days
- GI instability-14
- Treatment adherence+8
- Nutritional resilience+7
- Inflammatory activity-5
- Toxicity+5
What helped?
- Dietary Support Protocol NP-02Day 31Result: no meaningful change
- GI Support Protocol GI-04Day 50Result: symptom burden −32%
LIFE OS recommendation
Monitoring Escalation ME-01
72%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion45.9/100
worsening · +6.3 vs previous 14 d
Toxicity
Blood46.6/100
worsening · +2.0 vs previous 14 d
Sleep quality
Wearable24.3/100
worsening · -7.4 vs previous 14 d
Energy level
Daily log3.3/10
worsening · -0.4 vs previous 14 d
Stress level
Daily log5.3/10
stable · -0.0 vs previous 14 d
Steps
Wearable1,201
worsening · -591 vs previous 14 d
Adherence
Companion55.4 %
improving · +2.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 43 from the failing basin, 45 from restoration.
Would help
Would not help
- NP-02 Dietary Support Protocolalready tried, no meaningful change
- Keep fat lowGI +5.1 next day on high-intake days · n 14
- Keep histamine lowGI +4.1 next day on high-intake days · n 16
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+5.1detractor · 95%
- Histamine load+4.1detractor · 95%
- Insoluble fibre+1.5no signal · 33%
- Simple carbohydrates+1.2no signal · 20%
- Alcohol-1no signal · 19%
- Spicy / capsaicin+0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 43/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑65
- WearableResting HR 74 bpm
- Wearable1,201 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 46 and rising
- WearableSleep 5.7 h, below personal baseline
- Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 50
- Drug metabolism and exposure ↑20
- BloodToxicity index 47
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 3.1 · butyrate capacity 43/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 41 ms
- Sleep
- 5.2 h
- Steps
- 1,686
- Resting HR
- 73 bpm
Daily log: GI score 46, nutritional resilience 46, adherence 55.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01327 | 43% | S01 | GI-04 | improved | 56 |
| P-01688 | 38% | S01 | GI-04 | improved | 40 |
| P-01310 | 36% | S01 | — | — | 57 |
| P-01813 | 32% | S01 | NP-02 | no change | 40 |
| P-01877 | 29% | S01 | CR-01 | improved | 67 |
| P-01604 | 25% | S01 | — | — | 71 |
| P-01821 | 25% | S01 | — | — | 58 |
| P-01823 | 25% | S01 | — | — | 57 |
| P-01635 | 48% | S02 | GI-04 | improved | 49 |
| P-01452 | 37% | S02 | GI-04 | improved | 46 |
| P-01459 | 34% | S02 | — | — | 51 |
| P-01498 | 25% | S02 | — | — | 56 |