Patient P-01447
Synthetic patientNBL-101 · Day 110 · 55–64 · M · baseline S15Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
60%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S15
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 50 GI-04 recommended — GI Support Protocol GI-04
- Day 51 Patient accepted — Started GI-04 in the companion
- Day 59 GI symptom burden −27% vs expected — GI Support Protocol GI-04
- Day 65 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- Toxicity-15
- Treatment adherence+4
- Inflammatory activity+3
- Nutritional resilience+2
What helped?
- GI Support Protocol GI-04Day 50Result: symptom burden −27%
LIFE OS recommendation
Dietary Support Protocol NP-02
53%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion60.2/100
stable · +1.7 vs previous 14 d
Toxicity
Blood38.7/100
improving · -10.7 vs previous 14 d
Sleep quality
Wearable12.6/100
improving · +2.9 vs previous 14 d
Energy level
Daily log2.7/10
improving · +0.3 vs previous 14 d
Stress level
Daily log6/10
improving · -0.5 vs previous 14 d
Steps
Wearable3,419
improving · +623 vs previous 14 d
Adherence
Companion49 %
improving · +2.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 23 from the failing basin, 67 from restoration.
Would help
Would not help
- Keep histamine lowGI +4.9 next day on high-intake days · n 22
- Keep simple carbs lowGI +4.7 next day on high-intake days · n 19
- Keep fat lowGI +4.4 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+4.9detractor · 95%
- Simple carbohydrates+4.7detractor · 95%
- Dietary fat load+4.4detractor · 95%
- Spicy / capsaicin+2.5detractor · 64%
- Insoluble fibre-0.6no signal · 15%
- Alcohol-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 60 and rising
- WearableSleep 5.5 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 61
- WearableHRV 38 ms, trending down
- Autonomic recovery ↑65
- WearableResting HR 83 bpm
- Wearable3,419 steps/day
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 5.9 h
- Steps
- 3,509
- Resting HR
- 79 bpm
Daily log: GI score 60, nutritional resilience 38, adherence 49.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01327 | 41% | S01 | GI-04 | improved | 56 |
| P-01688 | 41% | S01 | GI-04 | improved | 40 |
| P-01813 | 41% | S01 | NP-02 | no change | 40 |
| P-01310 | 34% | S01 | — | — | 57 |
| P-01877 | 29% | S01 | CR-01 | improved | 67 |
| P-01823 | 22% | S01 | — | — | 57 |
| P-01604 | 21% | S01 | — | — | 71 |
| P-01821 | 21% | S01 | — | — | 58 |
| P-01846 | 21% | S01 | — | — | 37 |
| P-01452 | 41% | S02 | GI-04 | improved | 46 |
| P-01635 | 40% | S02 | GI-04 | improved | 49 |
| P-01459 | 32% | S02 | — | — | 51 |