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Patient P-01448

Synthetic patientNBL-101 · Day 116 · 35–44 · M · baseline S10Steering view · 3DOpen companion preview
Therapy response
Favorable
Tolerance
Favorable
GI state
Favorable
Inflammatory state
Favorable
Nutritional resilience
Stable
Discontinuation risk
21%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S10

What changed?

Trajectory is tracking the baseline prediction.

Primary contributors, last 14 days
  • Treatment adherence+4
  • GI instability-3
  • Nutritional resilience+3
  • Toxicity+3
  • Inflammatory activity+2

What helped?

No interventions yet.

    LIFE OS recommendation
    No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    31.4/100
    worsening · +2.9 vs previous 14 d
    Toxicity
    Blood
    18.6/100
    worsening · +4.5 vs previous 14 d
    Sleep quality
    Wearable
    28.6/100
    improving · +2.7 vs previous 14 d
    Energy level
    Daily log
    5.1/10
    worsening · -0.3 vs previous 14 d
    Stress level
    Daily log
    5.1/10
    stable · -0.0 vs previous 14 d
    Steps
    Wearable
    9,366
    stable · -276 vs previous 14 d
    Adherence
    Companion
    90.9 %
    worsening · -5.2 vs previous 14 d
    This trajectory is doing well — what to keep, what to watch
    Steering view →

    Heading towards restoration · 79 from the failing basin, 16 from restoration.

    Good elements to keep
    • Butyrate producers intact
      hidden · steering +7.5
    • Daily walks resumed
      perturbation · steering +3.3
    Main detractors to watch
    • FUT2 non-secretor
      hidden · steering -10.6
    • Bacteroides fragilis elevated
      hidden · steering -7.4
    • IL6 high-expression variant
      hidden · steering -7.3
    • Histamine load
      perturbation · steering -6.7
    • Histamine load
      detractor · GI +3.9 next day
    • Spicy / capsaicin
      detractor · GI +3.7 next day
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +3.9detractor · 95%
    • Spicy / capsaicin
      +3.7detractor · 95%
    • Alcohol
      +3.3detractor · 95%
    • Dietary fat load
      -0.8no signal · 18%
    • Insoluble fibre
      +0.6no signal · 16%
    • Simple carbohydrates
      +0.2no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Inflammatory signalling ↑60
      • DNAIL6 -174 variant raises baseline inflammatory tone
      • MicrobiomeBacteroides fragilis expansion
      • WearableHRV 34 ms, trending down
    • Mucosal barrier integrity ↓40
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • WearableSleep 5.9 h, below personal baseline
    • Butyrate / short-chain fatty acid production ↓25
      • MicrobiomeF. prausnitzii depleted
    • Autonomic recovery ↓20
      • WearableShort sleep window
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • IL6 -174 G/C
      Higher inflammatory tone
    • CYP2D6 Intermediate metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 3.2 · butyrate capacity 67/100
    • Akkermansia muciniphilaNormal
    • Faecalibacterium prausnitziiLow
    • Bacteroides fragilisHigh
    • Bifidobacterium longumNormal
    • EnterobacteriaceaeHigh
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    41 ms
    Sleep
    6.3 h
    Steps
    9,115
    Resting HR
    70 bpm
    Daily log: GI score 31, nutritional resilience 59, adherence 91.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • Keep the current walking rhythm
    • Protect a 7.5-hour sleep window; screens off 30 minutes before
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

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    P-0139936%S01——83
    P-0140835%S01——77
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    P-0145525%S01GI-04improved61