Patient P-01448
Therapy response 85 at the day-84 endpoint (observed).
Responding: response probability 89%, therapy response 94 today; biology is not blocking the drug.
No side effect starting: gi toxicity 16, systemic toxicity 14, no drift from the model.
9 of 9 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +3 bpm, HRV −8 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01448 is on day 117 of NBL-101 (SR, baseline S17): response improving, tolerance favorable, GI deteriorating. Over 14 days response moved +14 and GI +6; discontinuation risk is 18%. The state is in the restoration basin, heading towards restoration.
Butyrate capacity 70/100, diversity 3.7, rapid metabolizer. Pushing it down: Klebsiella pneumoniae 3.956% (LPS load) (-19.3), Alcohol (-17.1), Rapid metabolizer (-13). Pulling it up: Butyrate producers intact (+12.1), Daily walks resumed (+3.3). From the daily log: alcohol +5.1 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S17
What changed?
Trajectory is tracking the baseline prediction.
- GI instability+6
- Treatment adherence+6
- Inflammatory activity+3
- Toxicity+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 100 from the failing basin, 16 from restoration.
- Butyrate producers intacthidden · steering +12.1
- Daily walks resumedperturbation · steering +3.3
- Klebsiella pneumoniae 3.956% (LPS load)hidden · steering -19.3
- Alcoholperturbation · steering -17.1
- Rapid metabolizerhidden · steering -13
- Enterobacteriaceae elevatedhidden · steering -12
- Alcoholdetractor · GI +5.1 next day
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Alcohol+5.1detractor · 95%
- Histamine load+2.2no signal · 41%
- Spicy / capsaicin-1.2no signal · 24%
- Dietary fat load+0.5no signal · 15%
- Insoluble fibre+0.4no signal · 15%
- Simple carbohydrates-0.1no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 2 opportunists above range: Klebsiella pneumoniae, Streptococcus gallolyticus
- 2 keystone species absent
- 6 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
- HRV
- 51 ms
- Sleep
- 6.6 h
- Steps
- 5,558
- Resting HR
- 60 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01481 | 31% | S15 | AD-05 | no change | 67 |
| P-01468 | 24% | S03 | AD-05 | no change | 50 |
| P-01764 | 49% | S15 | BR-03 | no change | 85 |
| P-01489 | 43% | S05 | BR-03 | improved | 83 |
| P-01766 | 40% | S01 | BR-03 | improved | 83 |
| P-01411 | 37% | S13 | BR-03 | no change | 76 |
| P-01664 | 38% | S07 | CR-01 | improved | 85 |
| P-01896 | 35% | S06 | CR-01 | improved | 73 |
| P-01725 | 25% | S01 | CR-01 | improved | 62 |
| P-01428 | 40% | S18 | DT-01 | improved | 82 |
| P-01472 | 39% | S20 | DT-01 | no change | 82 |
| P-01528 | 34% | S20 | DT-01 | improved | 89 |