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Patient P-01451

Synthetic patientNBL-101 · Day 117 · 75+ · F · baseline S12Steering view · 3DOpen companion preview
Therapy response
Unstable
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
43%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S12
  2. Day 22 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 22.

Primary contributors, last 14 days
  • Toxicity+23
  • Inflammatory activity+19
  • GI instability+13
  • Nutritional resilience-12
  • Treatment adherence+3

What helped?

No interventions yet.

    LIFE OS recommendation
    No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    31/100
    worsening · +2.9 vs previous 14 d
    Toxicity
    Blood
    29.7/100
    worsening · +19.1 vs previous 14 d
    Sleep quality
    Wearable
    47.3/100
    stable · -1.1 vs previous 14 d
    Energy level
    Daily log
    4.5/10
    worsening · -0.7 vs previous 14 d
    Stress level
    Daily log
    4.8/10
    worsening · +0.9 vs previous 14 d
    Steps
    Wearable
    3,600
    worsening · -628 vs previous 14 d
    Adherence
    Companion
    84.6 %
    stable · -2.3 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards failing · 48 from the failing basin, 58 from restoration.

    Would help
    • No untried action with strong evidence. Compose one from primitives.
    Would not help
    • Keep alcohol low
      GI +4.7 next day on high-intake days · n 17
    • Keep spicy low
      GI +3.3 next day on high-intake days · n 17
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Alcohol
      +4.7detractor · 95%
    • Spicy / capsaicin
      +3.3detractor · 71%
    • Histamine load
      -1.1no signal · 20%
    • Simple carbohydrates
      -0.5no signal · 15%
    • Dietary fat load
      +0.4no signal · 15%
    • Insoluble fibre
      -0.2no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Drug metabolism and exposure ↑35
      • DNADPYD *2A → slower clearance
    • Mucosal barrier integrity ↓30
      • MicrobiomeAkkermansia low → thinner mucus layer
    • Inflammatory signalling ↑25
      • DNAIL6 -174 variant raises baseline inflammatory tone
    • Autonomic recovery ↓20
      • Wearable3,600 steps/day
    DNA
    Fictional pharmacogenomic panel
    • IL6 -174 G/C
      Higher inflammatory tone
    • DPYD *2A heterozygous
      Slower drug clearance
    • CYP2D6 Rapid metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 3.4 · butyrate capacity 81/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisNormal
    • Bifidobacterium longumLow
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    45 ms
    Sleep
    7.4 h
    Steps
    4,013
    Resting HR
    65 bpm
    Daily log: GI score 31, nutritional resilience 55, adherence 85.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Keep fibre steady; no new sources this week
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • A 15-minute walk after lunch
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0177335%S05AD-05improved27
    P-0148328%S14AD-05no change35
    P-0137727%S11AD-05no change42
    P-0167927%S12AD-05no change39
    P-0154125%S09AD-05no change43
    P-0184824%S05AD-05no change23
    P-0180423%S19AD-05improved61
    P-0131329%S01BR-03improved32
    P-0145027%S09BR-03no change36
    P-0135026%S19BR-03no change34
    P-0168925%S13BR-03no change50
    P-0146823%S06BR-03no change41