Patient P-01454
Therapy response
Improving
Tolerance
Stable
GI state
Improving
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
75%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 44 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 54 GI-04 recommended — GI Support Protocol GI-04
- Day 55 Patient accepted — Started GI-04 in the companion
- Day 63 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 44.
Primary contributors, last 14 days
- GI instability-7
- Treatment adherence-2
What helped?
- GI Support Protocol GI-04Day 54Result: no meaningful change
LIFE OS recommendation
Dietary Support Protocol NP-02
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion57/100
improving · -4.0 vs previous 14 d
Toxicity
Blood56.7/100
worsening · +3.5 vs previous 14 d
Sleep quality
Wearable35.5/100
improving · +2.1 vs previous 14 d
Energy level
Daily log2.9/10
stable · +0.1 vs previous 14 d
Stress level
Daily log8.1/10
stable · -0.2 vs previous 14 d
Steps
Wearable5,847
stable · +154 vs previous 14 d
Adherence
Companion44.3 %
improving · +2.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 28 from the failing basin, 63 from restoration.
Would help
Would not help
- GI-04 GI Support Protocolalready tried, no meaningful change
- Keep fat lowGI +4.5 next day on high-intake days · n 21
- Keep simple carbs lowGI +4 next day on high-intake days · n 18
- Keep fibre lowGI +3.3 next day on high-intake days · n 16
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+4.5detractor · 95%
- Simple carbohydrates+4detractor · 95%
- Insoluble fibre+3.3detractor · 90%
- Alcohol+3.2detractor · 87%
- Spicy / capsaicin-1.3no signal · 24%
- Histamine load-0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 62
- WearableHRV 19 ms, trending down
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 28/100
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 57 and rising
- Autonomic recovery ↓25
- WearableResting HR 87 bpm
- Drug metabolism and exposure ↑20
- BloodToxicity index 57
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.5 · butyrate capacity 28/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 23 ms
- Sleep
- 6.8 h
- Steps
- 5,836
- Resting HR
- 86 bpm
Daily log: GI score 57, nutritional resilience 35, adherence 44.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01804 | 18% | S19 | AD-05 | improved | 61 |
| P-01377 | 17% | S11 | AD-05 | no change | 42 |
| P-01708 | 26% | S07 | CR-01 | improved | 59 |
| P-01696 | 25% | S20 | CR-01 | improved | 59 |
| P-01371 | 24% | S06 | CR-01 | improved | 63 |
| P-01835 | 24% | S17 | CR-01 | improved | 56 |
| P-01388 | 23% | S17 | CR-01 | improved | 59 |
| P-01442 | 23% | S13 | CR-01 | improved | 61 |
| P-01877 | 23% | S01 | CR-01 | improved | 67 |
| P-01430 | 18% | S05 | CR-01 | improved | 54 |
| P-01767 | 18% | S14 | DT-01 | no change | 63 |
| P-01342 | 17% | S11 | DT-01 | improved | 48 |