Patient P-01459
Synthetic patientNBL-101 · Day 108 · 35–44 · F · baseline S02Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Stable
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
66%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S02
- Day 79 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 79.
Primary contributors, last 14 days
- Treatment adherence-13
- GI instability+7
- Nutritional resilience-6
- Toxicity+3
- Inflammatory activity+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
67%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion61/100
worsening · +12.3 vs previous 14 d
Toxicity
Blood49.8/100
worsening · +11.4 vs previous 14 d
Sleep quality
Wearable29.7/100
worsening · -5.4 vs previous 14 d
Energy level
Daily log2.7/10
worsening · -1.0 vs previous 14 d
Stress level
Daily log7.5/10
worsening · +1.0 vs previous 14 d
Steps
Wearable967
worsening · -745 vs previous 14 d
Adherence
Companion63.8 %
worsening · -13.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 31 from the failing basin, 61 from restoration.
Would help
Would not help
- Keep histamine lowGI +5.1 next day on high-intake days · n 26
- Keep fat lowGI +4 next day on high-intake days · n 25
- Keep spicy lowGI +3.9 next day on high-intake days · n 27
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.1detractor · 95%
- Dietary fat load+4detractor · 95%
- Spicy / capsaicin+3.9detractor · 95%
- Alcohol-2.5no signal · 53%
- Simple carbohydrates+1.3no signal · 24%
- Insoluble fibre-0.8no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 28/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 57
- WearableHRV 38 ms, trending down
- Autonomic recovery ↓65
- WearableResting HR 73 bpm
- Wearable967 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 61 and rising
- WearableSleep 5.9 h, below personal baseline
- Drug metabolism and exposure ↑20
- BloodToxicity index 50
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 28/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 37 ms
- Sleep
- 6.4 h
- Steps
- 1,304
- Resting HR
- 71 bpm
Daily log: GI score 61, nutritional resilience 40, adherence 64.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01388 | 49% | S17 | CR-01 | improved | 59 |
| P-01696 | 47% | S20 | CR-01 | improved | 59 |
| P-01371 | 44% | S06 | CR-01 | improved | 63 |
| P-01699 | 42% | S04 | GI-04 | improved | 69 |
| P-01835 | 40% | S17 | CR-01 | improved | 56 |
| P-01442 | 38% | S13 | CR-01 | improved | 61 |
| P-01708 | 38% | S07 | CR-01 | improved | 59 |
| P-01635 | 37% | S02 | GI-04 | improved | 49 |
| P-01877 | 37% | S01 | CR-01 | improved | 67 |
| P-01611 | 36% | S14 | GI-04 | improved | 44 |
| P-01349 | 35% | S14 | GI-04 | improved | 38 |
| P-01452 | 35% | S02 | GI-04 | improved | 46 |