Patient P-01462

Synthetic patientNBL-101 · Day 112 · 65–74 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Stable

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Unstable

Discontinuation risk

75%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −26% vs expected — Dietary Support Protocol NP-02
Day 48 Tolerance state changed — Unstable → Improving
Day 59 GI-04 recommended — GI Support Protocol GI-04
Day 60 Patient accepted — Started GI-04 in the companion
Day 62 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 68 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 62.

Primary contributors, last 14 days

Nutritional resilience-8
GI instability+4
Toxicity+3
Inflammatory activity+2

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −26%
GI Support Protocol GI-04Day 59
Result: no meaningful change

LIFE OS recommendation

Monitoring Escalation ME-01

88%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

57.9/100

improving · -5.6 vs previous 14 d

Toxicity

Blood

49.2/100

stable · +0.6 vs previous 14 d

Sleep quality

Wearable

26.5/100

stable · +0.6 vs previous 14 d

Energy level

Daily log

2.8/10

stable · +0.1 vs previous 14 d

Stress level

Daily log

6.9/10

stable · -0.1 vs previous 14 d

Steps

Wearable

4,726

improving · +254 vs previous 14 d

Adherence

Companion

50.9 %

stable · -2.0 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 30 from the failing basin, 59 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 76%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 76%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 76%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep fibre low
GI +2.2 next day on high-intake days · n 17
Keep fat low
GI +1.9 next day on high-intake days · n 22

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Insoluble fibre
+2.2detractor · 55%
Spicy / capsaicin
-2.1no signal · 46%
Dietary fat load
+1.9detractor · 55%
Alcohol
-0.7no signal · 16%
Simple carbohydrates
-0.4no signal · 15%
Histamine load
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 52
- WearableHRV 23 ms, trending down
Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 49
Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 58 and rising
Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 3 · butyrate capacity 47/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 22 ms
Sleep: 6.8 h
Steps: 5,370
Resting HR: 65 bpm

Daily log: GI score 58, nutritional resilience 36, adherence 51.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01692	65%	S14	NP-02	improved	49
P-01872	63%	S14	NP-02	improved	47
P-01364	62%	S14	GI-04	improved	49
P-01393	62%	S14	GI-04	improved	53
P-01496	61%	S14	SC-12	improved	46
P-01865	60%	S14	NP-02	no change	51
P-01879	60%	S14	SC-12	improved	51
P-01573	58%	S14	GI-04	improved	49
P-01409	56%	S14	SC-12	improved	41
P-01433	56%	S14	GI-04	improved	48
P-01624	55%	S14	GI-04	improved	52
P-01834	55%	S14	NP-02	improved	44