Patient P-01465

Synthetic patientNBL-101 · Day 110 · 35–44 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Deteriorating

Nutritional resilience

Improving

Discontinuation risk

80%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −15% vs expected — Dietary Support Protocol NP-02
Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 48 Tolerance state changed — Unstable → Improving
Day 48 SC-12 recommended — Supportive Compound SC-12
Day 49 Patient accepted — Started SC-12 in the companion
Day 51 GI-04 recommended — GI Support Protocol GI-04
Day 52 Patient accepted — Started GI-04 in the companion
Day 55 No meaningful change — Supportive Compound SC-12
Day 60 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 47.

Primary contributors, last 14 days

Inflammatory activity+10
Toxicity+9
GI instability+5
Nutritional resilience+5
Treatment adherence-5

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −15%
Supportive Compound SC-12Day 48
Result: no meaningful change
GI Support Protocol GI-04Day 51
Result: no meaningful change

LIFE OS recommendation

Monitoring Escalation ME-01

92%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

59.6/100

stable · -0.4 vs previous 14 d

Toxicity

Blood

53.8/100

worsening · +2.2 vs previous 14 d

Sleep quality

Wearable

11.4/100

worsening · -4.8 vs previous 14 d

Energy level

Daily log

2.5/10

worsening · -0.1 vs previous 14 d

Stress level

Daily log

7.4/10

worsening · +0.4 vs previous 14 d

Steps

Wearable

6,226

worsening · -291 vs previous 14 d

Adherence

Companion

45 %

worsening · -4.8 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 35 from the failing basin, 59 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 81%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 81%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
SC-12 Supportive Compound
already tried, no meaningful change
Keep fat low
GI +6.5 next day on high-intake days · n 29
Keep simple carbs low
GI +5.1 next day on high-intake days · n 19

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+6.5detractor · 95%
Simple carbohydrates
+5.1detractor · 95%
Spicy / capsaicin
-2.5no signal · 39%
Insoluble fibre
+2.1no signal · 36%
Alcohol
-1.1no signal · 20%
Histamine load
+0.9no signal · 16%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 60 and rising
- WearableSleep 5.5 h, below personal baseline
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 33/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
Inflammatory signalling ↑40
- BloodInflammatory load index 57
- WearableHRV 34 ms, trending down
Drug metabolism and exposure ↑20
- BloodToxicity index 54

DNA

Fictional pharmacogenomic panel

CYP2D6 Rapid metabolizer
Expected exposure

Microbiome

Shannon diversity 2.9 · butyrate capacity 33/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 32 ms
Sleep: 5.8 h
Steps: 6,810
Resting HR: 78 bpm

Daily log: GI score 60, nutritional resilience 44, adherence 45.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01339	58%	S14	GI-04	improved	54
P-01360	55%	S14	GI-04	improved	52
P-01393	55%	S14	GI-04	improved	53
P-01496	55%	S14	SC-12	improved	46
P-01595	55%	S14	GI-04	no change	51
P-01417	54%	S14	GI-04	improved	65
P-01732	53%	S14	ME-01	improved	45
P-01433	52%	S14	GI-04	improved	48
P-01692	51%	S14	NP-02	improved	49
P-01834	51%	S14	NP-02	improved	44
P-01364	50%	S14	GI-04	improved	49
P-01573	50%	S14	GI-04	improved	49