Patient P-01469
Therapy response
Stable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
58%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S19
- Day 80 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 80.
Primary contributors, last 14 days
- Toxicity+13
- GI instability-6
- Nutritional resilience+4
- Inflammatory activity-2
- Treatment adherence-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion62.4/100
worsening · +2.7 vs previous 14 d
Toxicity
Blood56.3/100
stable · +0.1 vs previous 14 d
Sleep quality
Wearable14.4/100
worsening · -5.6 vs previous 14 d
Energy level
Daily log1.9/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log7.6/10
stable · +0.3 vs previous 14 d
Steps
Wearable1,185
improving · +150 vs previous 14 d
Adherence
Companion70.8 %
worsening · -5.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 35 from the failing basin, 62 from restoration.
Would help
Would not help
- Keep fat lowGI +6.2 next day on high-intake days · n 20
- Keep simple carbs lowGI +6 next day on high-intake days · n 18
- Keep alcohol lowGI +5.1 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+6.2detractor · 95%
- Simple carbohydrates+6detractor · 95%
- Alcohol+5.1detractor · 95%
- Spicy / capsaicin+1no signal · 17%
- Histamine load-0.6no signal · 15%
- Insoluble fibre-0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑65
- WearableResting HR 85 bpm
- Wearable1,185 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 62 and rising
- WearableSleep 5.4 h, below personal baseline
- Inflammatory signalling ↓40
- BloodInflammatory load index 60
- WearableHRV 27 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 56
DNA
Fictional pharmacogenomic panel
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 32/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 28 ms
- Sleep
- 5.0 h
- Steps
- 2,343
- Resting HR
- 86 bpm
Daily log: GI score 62, nutritional resilience 39, adherence 71.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01877 | 47% | S01 | CR-01 | improved | 67 |
| P-01835 | 45% | S17 | CR-01 | improved | 56 |
| P-01388 | 43% | S17 | CR-01 | improved | 59 |
| P-01696 | 43% | S20 | CR-01 | improved | 59 |
| P-01699 | 41% | S04 | GI-04 | improved | 69 |
| P-01708 | 40% | S07 | CR-01 | improved | 59 |
| P-01442 | 37% | S13 | CR-01 | improved | 61 |
| P-01433 | 36% | S14 | GI-04 | improved | 48 |
| P-01371 | 35% | S06 | CR-01 | improved | 63 |
| P-01393 | 34% | S14 | GI-04 | improved | 53 |
| P-01349 | 33% | S14 | GI-04 | improved | 38 |
| P-01647 | 33% | S14 | GI-04 | improved | 64 |