Patient P-01492
Synthetic patientNBL-101 · Day 112 · 35–44 · F · baseline S15Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
86%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S15
- Day 52 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 54 GI-04 recommended — GI Support Protocol GI-04
- Day 55 Patient declined — Not now
- Day 70 ME-01 recommended — Monitoring Escalation ME-01
- Day 71 Patient accepted — Started ME-01 in the companion
- Day 74 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 52.
Primary contributors, last 14 days
- GI instability-15
- Inflammatory activity-14
- Nutritional resilience+4
- Treatment adherence+2
What helped?
- GI Support Protocol GI-04Day 54Declined by patient
- Monitoring Escalation ME-01Day 70Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion64.5/100
stable · -2.0 vs previous 14 d
Toxicity
Blood60.2/100
improving · -2.8 vs previous 14 d
Sleep quality
Wearable27.5/100
stable · -0.9 vs previous 14 d
Energy level
Daily log2.2/10
stable · +0.0 vs previous 14 d
Stress level
Daily log7.5/10
stable · -0.1 vs previous 14 d
Steps
Wearable300
stable · +4 vs previous 14 d
Adherence
Companion49.4 %
stable · -1.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 21 from the failing basin, 71 from restoration.
Would help
Would not help
- Keep fibre lowGI +4.5 next day on high-intake days · n 21
- Keep histamine lowGI +3.6 next day on high-intake days · n 21
- Keep simple carbs lowGI +3.5 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Insoluble fibre+4.5detractor · 95%
- Histamine load+3.6detractor · 95%
- Simple carbohydrates+3.5detractor · 88%
- Alcohol-1.9no signal · 35%
- Spicy / capsaicin-0.8no signal · 15%
- Dietary fat load-0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 63
- WearableHRV 22 ms, trending down
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 65 and rising
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 78 bpm
- Wearable300 steps/day
- Drug metabolism and exposure ↑20
- BloodToxicity index 60
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.1 · butyrate capacity 47/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 19 ms
- Sleep
- 6.6 h
- Steps
- 422
- Resting HR
- 79 bpm
Daily log: GI score 65, nutritional resilience 27, adherence 49.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01813 | 43% | S01 | NP-02 | no change | 40 |
| P-01327 | 33% | S01 | GI-04 | improved | 56 |
| P-01310 | 27% | S01 | — | — | 57 |
| P-01688 | 27% | S01 | GI-04 | improved | 40 |
| P-01877 | 23% | S01 | CR-01 | improved | 67 |
| P-01604 | 17% | S01 | — | — | 71 |
| P-01821 | 17% | S01 | — | — | 58 |
| P-01823 | 17% | S01 | — | — | 57 |
| P-01452 | 28% | S02 | GI-04 | improved | 46 |
| P-01635 | 28% | S02 | GI-04 | improved | 49 |
| P-01459 | 23% | S02 | — | — | 51 |
| P-01498 | 17% | S02 | — | — | 56 |