Patient P-01514

Synthetic patientNBL-101 · Day 109 · 45–54 · F · baseline S11Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

65%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S11
Day 79 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 79.

Primary contributors, last 14 days

Toxicity+13
Inflammatory activity+12
Treatment adherence-12
Nutritional resilience-9
GI instability+4

What helped?

No interventions yet.

LIFE OS recommendation

GI Support Protocol GI-04

66%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

60.3/100

stable · +0.1 vs previous 14 d

Toxicity

Blood

54.5/100

worsening · +7.7 vs previous 14 d

Sleep quality

Wearable

8/100

stable · -0.3 vs previous 14 d

Energy level

Daily log

2.1/10

worsening · -0.4 vs previous 14 d

Stress level

Daily log

7.6/10

stable · +0.1 vs previous 14 d

Steps

Wearable

6,373

stable · -277 vs previous 14 d

Adherence

Companion

62.2 %

worsening · -12.2 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 40 from the failing basin, 61 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 124 similar · onset 8 d · confidence 65%
ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 73%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 73%

Would not help

Keep fat low
GI +6.3 next day on high-intake days · n 18
Keep histamine low
GI +5.4 next day on high-intake days · n 22
Keep alcohol low
GI +4.8 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+6.3detractor · 95%
Histamine load
+5.4detractor · 95%
Alcohol
+4.8detractor · 95%
Spicy / capsaicin
+4.7detractor · 95%
Simple carbohydrates
+4.3detractor · 95%
Insoluble fibre
-0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 63
- WearableHRV 18 ms, trending down
Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 60 and rising
- WearableSleep 5.4 h, below personal baseline
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 40/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↓45
- WearableResting HR 81 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 55

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Intermediate metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.7 · butyrate capacity 40/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 21 ms
Sleep: 5.4 h
Steps: 7,104
Resting HR: 80 bpm

Daily log: GI score 60, nutritional resilience 33, adherence 62.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01804	21%	S19	AD-05	improved	61
P-01835	51%	S17	CR-01	improved	56
P-01877	44%	S01	CR-01	improved	67
P-01388	43%	S17	CR-01	improved	59
P-01371	37%	S06	CR-01	improved	63
P-01696	37%	S20	CR-01	improved	59
P-01708	37%	S07	CR-01	improved	59
P-01442	35%	S13	CR-01	improved	61
P-01430	21%	S05	CR-01	improved	54
P-01342	21%	S11	DT-01	improved	48
P-01767	21%	S14	DT-01	no change	63
P-01699	37%	S04	GI-04	improved	69