Patient P-01529
Synthetic patientNBL-101 · Day 98 · 45–54 · F · baseline S20Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
54%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S20
- Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 52 GI-04 recommended — GI Support Protocol GI-04
- Day 53 Patient accepted — Started GI-04 in the companion
- Day 61 GI symptom burden −34% vs expected — GI Support Protocol GI-04
- Day 67 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 49.
Primary contributors, last 14 days
- Toxicity+17
- Inflammatory activity+7
- Treatment adherence+5
- GI instability-3
- Nutritional resilience-3
What helped?
- GI Support Protocol GI-04Day 52Result: symptom burden −34%
LIFE OS recommendation
Dietary Support Protocol NP-02
54%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion45.2/100
improving · -2.3 vs previous 14 d
Toxicity
Blood54/100
worsening · +21.0 vs previous 14 d
Sleep quality
Wearable23.4/100
improving · +1.8 vs previous 14 d
Energy level
Daily log3/10
worsening · -0.4 vs previous 14 d
Stress level
Daily log6.1/10
worsening · +0.5 vs previous 14 d
Steps
Wearable7,001
worsening · -585 vs previous 14 d
Adherence
Companion53.5 %
worsening · -7.6 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 33 from the failing basin, 54 from restoration.
Would help
Would not help
- Keep histamine lowGI +6.4 next day on high-intake days · n 22
- Keep fat lowGI +6.3 next day on high-intake days · n 21
- Keep simple carbs lowGI +5.5 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+6.4detractor · 95%
- Dietary fat load+6.3detractor · 95%
- Simple carbohydrates+5.5detractor · 95%
- Spicy / capsaicin+4.7detractor · 95%
- Insoluble fibre+4.1detractor · 95%
- Alcohol+3.9detractor · 95%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑95
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- BloodToxicity index 54
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 45 and rising
- WearableSleep 6.1 h, below personal baseline
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 54
- WearableHRV 34 ms, trending down
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 32/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2 · butyrate capacity 32/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 33 ms
- Sleep
- 5.7 h
- Steps
- 6,069
- Resting HR
- 78 bpm
Daily log: GI score 45, nutritional resilience 42, adherence 54.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01804 | 22% | S19 | AD-05 | improved | 61 |
| P-01689 | 22% | S13 | BR-03 | no change | 50 |
| P-01371 | 28% | S06 | CR-01 | improved | 63 |
| P-01696 | 28% | S20 | CR-01 | improved | 59 |
| P-01708 | 28% | S07 | CR-01 | improved | 59 |
| P-01388 | 26% | S17 | CR-01 | improved | 59 |
| P-01442 | 26% | S13 | CR-01 | improved | 61 |
| P-01835 | 26% | S17 | CR-01 | improved | 56 |
| P-01430 | 23% | S05 | CR-01 | improved | 54 |
| P-01877 | 23% | S01 | CR-01 | improved | 67 |
| P-01767 | 22% | S14 | DT-01 | no change | 63 |
| P-01486 | 46% | S18 | GI-04 | improved | 47 |